Knut-Erik Tollefsen

• Ecotoxicology
• Aquatic pollution
• Methodology in Environmental Risk Assessment
• Genomics
• Monitoring and treatment of water contaminants of emerging concern

Liste med publikasjoner fra min forskning. (Cristin)

Peer-reviewed ISI publications (total 143)

Toyota, K., Watanabe, H., Hirano, M., Abe, R., Miyakawa, H., Song, Y., Sato, T., Miyagawa, S., Tollefsen, K.E., Tatarazako, N., Iguchi, T. (In press) Juvenile hormone synthesis and signaling disruption triggering male offspring induction and population decline in cladocerans: Review and adverse outcome pathway development. Aquatic Toxuicol.

Chauhan, V., Beaton, D., Hamada, N., Wilkins, R., Burtt, J., Leblanc, J., Cool, D., Garnier-Laplace, J., Laurier, D., Le, Y., Yamada, Y., Tollefsen, K.E. (In press). Adverse Outcome Pathway: A Path towards better Data Consolidation and Global Co-ordination of Radiation Research. Int. J. of Rad. Biol.

Mentzell, S., Grung, M., Tollefsen, K.E., Stenrød, M., Petersen, K., Moe, J.S. (In press). Development of a Bayesian network for probabilistic risk assessment of pesticides. Integrated Environmental Assessment and Management.

Lerebours, A., Murzina, S., Song, Y., Tollefsen, K.E., Benedetti, M., Regoli, F., Rotchell, J.M., Nahrgang, J. (2021). Susceptibility of the key Arctic fish polar cod (boreogadus saida) to a model carcinogen. Marine Environmental Research 170: 105434. doi.org/10.1016/j.marenvres.2021.105434

Schmid, S., Song, Y., Tollefsen, K.E. (2021). Inhibition of Chitin Synthase 1 leading to Increased Mortality in Arthropods. Environ. Toxicol. Chem. Pathways and predictions. 40: 2112–2120. doi.org/10.1002/etc.5058

Scheibener, S., Song, Y., Tollefsen, K.E., Salbu, B., Teien, H.C. (2021). Uranium accumulation and toxicokinetics in the crustacean Daphnia magna provide perspective to toxicodynamic responses. Aquatic toxicology. 235: 105836. doi.org/10.1016/j.aquatox.2021.105836

Wolf, R. and Tollefsen, K.E. (2021). A bayesian approach to incorporating spatiotemporal variation and uncertainty limits into modeling of predicted environmental concentrations from chemical monitoring campaigns. Environ. Sci. Technol. 55(3): 1699–1709. doi.org/10.1021/acs.est.0c06268.

Moe, S.J., Wolf, R., Xie, L., Landis, W.G., Kotamäki, N., Tollefsen, K.E. (2021). Quantification of an Adverse Outcome Pathway network by Bayesian regression and Bayesian network modelling. Integrated Environmental Assessment and Management (IEAM). 1: 147-164. doi.org/10.1002/ieam.4348.

Xie, L., Solhaug, K.A., Song, Y., Johnsen, B, Tollefsen, K.E. (2020). Effects of artificial ultraviolet B radiation on the macrophyte Lemna minor: a conceptual study for toxicity pathway characterization. Planta. 252(5): 86.  doi: 10.1007/s00425-020-03482-3.

Song, Y., Xie, L., Lee, Y.K., Tollefsen, K.E. (2020). De novo Development of a Quantitative Adverse Outcome Pathway (qAOP) Network for Ultraviolet B (UVB) Radiation Using Targeted Laboratory Tests and Automated Data Mining. Environ. Sci. Technol. 54 (20): 13147–13156. DOI: 10.1021/acs.est.0c03794

Thaulow, J., Song, Y., Lindeman, L.C., Kamstra, J.H., Lee, Y., Xie, L., Aleström, P., Salbu, B., Tollefsen, K.E. (2020) Epigenetic, transcriptional and phenotypic responses in Daphnia magna exposed to low-level ionizing radiation. Environmental Research. 190: 109930.  doi.org/10.1016/j.envres. 2020.109930.

Mellor, C.L., Tollefsen, K.E., Lalone, C., Cronin, M.T.D. and Firman, J.W. (2020). In silico identification of chemicals capable of binding to the ecdysone receptor. Environ. Toxciol.Chem. 39 (7): 1438-1450. doi.org/10.1002/etc.4733

Song, Y., Xi, L., Leeb, Y. Brede, D.A., Lyne, F., Kassayeb, Y., Thaulow, J., Caldwell, G., Salbu, B., Tollefsen, K.E. (2020). Integrative assessment of low-dose gamma radiation effects on Daphnia magna reproduction: Toxicity pathway assembly and AOP development. Science of the Total Environment.705: 135912. doi.org/10.1016/j.scitotenv.2019.135912

Schirmer, K., Stadnicka, J., Belanger, S. Blaha, L., Bols, N., Dyer, S: Embry, M., Fischer, M., Halder, M., Hermens, J., Hultman, M.T.,  Kramer, N., Laue, H., Lee, L., Lillicrap, A, Natsch, A. Segner, H., Tanneberger, K., Tollefsen, K.E., Werner, I., Witters, H., and Zupanic, A. (2019). Cell-based data to predict the toxicity of chemicals to fish. Commentary on the manuscript by Rodrigues et al., 2019. Cell-based assays seem not to accurately predict fish short-term toxicity of pesticides. Environmental Pollution 252:476-482.

Faust, M., Backhaus, T., Altenburger, R., Dulio, V., van Gils, J., Ginebreda, A., Kortenkamp, A:, Munthe, J., Posthuma, L., Slobodnik, J., Tollefsen, K.E., van Wezel, A. amd Brack, W. (2019). Prioritisation of water pollutants. The EU Project SOLUTIONS proposes a methodological framework for the integration of mixture risk assessments into prioritisation procedures under the European Water Framework Directive.  Environ Sci Eur. 31: 66-70.

Lindeman, L.C., Thaulow, J., Song, Y., Kamstra, J.H., Xie, Li., Asselman, J., Aleström, P., Tollefsen, K.E. (2019). Epigenetic, transcriptional and phenotypic responses in two generations of Daphnia magna exposed to the DNA methylation inhibitor 5-Azacytidine. Environmental Epigenetics. 5.(3) s.dvz016.doi:  doi.org/10.1093/eep/dvz016

Blagojevic, D., Lee, Y.K., Xie, L., Brede, D.A., Nybakken, L., Lind, O.C., Tollefsen, K.E., Salbu, B., Solhaug, K.A., Olsen, J.E. (2019). No Evidence of a Protective or Cumulative Negative Effect of UV-B on Growth Inhibition Induced by Gamma Radiation in Scots Pine (Pinus Sylvestris) Seedlings. Photochemical & Photobiological Sciences. 18(8), 1945-1962.

Evenseth, L.M., Kristiansen, K., Song, Y., Tollefsen, K.E. Sylte, I. (2019) In silico site-directed mutagenesis of the Daphnia magna ecdysone receptor identifies critical amino acids for species-specific and inter-species differences in agonist binding. Comp. Toxicol. 12: 100091.  doi: doi.org/10.1016/j.comtox.2019.100091

Xie, L., Solhaug, K.A., Brede, D.A. Lind, O.C., Song, Y. Salbu, B., Tollefsen, K.E. (2019). Modes of action and adverse effects of gamma radiation in the aquatic macrophytes Lemna minor. Sci. Total. Environ. 680:23-34. doi: 10.1016/j.scitotenv.2019.05.016.

Salbu, B., Lind, O.C., Teien, H.C., Tollefsen, K.E. (2019). Why is the multiple stressor concept of relevance to radioecology? Int J. Rad Biol. 11:1-10. doi: 10.1080/09553002.2019.1605463

Almeida, A.C., Gomes, T., Langford, K., Thomas, K.V., Tollefsen, K.E. (2019). Oxidative stress potential of the herbicides bifenox and metribuzin in the microalgae Chlamydomonas reinhardtii. Aquatic Toxicology. 210:117-128. doi: 10.1016/j.aquatox.2019.02.021

Fischer, M., Belanger, S., Berckmans, P., Bernhard, M., Blaha, L.., Coman Schmid, D., Dyer, S., Haupt, T., Hermens, J., Hultman, M. T., Laue, H.; Lillicrap, A., Mlnaříková, M., Natsch, A., Novák, J.; Sinnige, T.; Tollefsen, K.E. von Niederhäusern, V., W, H., Zupanic, A., Schirmer, K. (2019). Repeatability and reproducibility of the RTgill-W1 cell line assay for predicting fish acute toxicity. Tox. Sci. 169: 353-364.

Song, Y., Nahrgang, J., Tollefsen, K.E. (2019). Transcriptomic analysis reveals dose-dependent toxic mechanisms of benzo(a)pyrene in polar cod (Boreogadus saida). Sci. Total. Environ. 653:176-189. doi: 10.1016/j.scitotenv.2018.10.261

Miyakawaa, H., Song, Y., Tollefsen, K.E., Iguchi, T. (2018). Ecdysteroid and juvenile hormone biosynthesis, receptors and their signaling in the freshwater microcrustacean Daphnia. J. Steroid Biochem. Mol. Biol. 184: 62-68.

Tousova,Z., Oswald,  P., Slobodnik, J., Blaha,L., Muz, M., Hu, M., Brack, W., Krauss, M., Di Paolo, C., Tarcai, Z., Seiler, T.B., Hollert, H., Koprivica, S., Ahel, M., Schollée, J.E., Hollender, J., Suter, M.J., Hidasi, A.O., Schirmer, K., Sonavane, M., Ait-Aissa, S., Creusot, N., Brion, F., Froment, J., Almeida, A.C., Thomas, K.V., Tollefsen, K.E., Tufi, S., Ouyang, X., Leonards, P., Lamoree, M., Torrens, V.O., Kolkman, A., Schriks, M., Spirhanzlova, P., Tindall, A. Schulze, T. (2018). Corrigendum to "European demonstration program on the effect-based and chemical identification and monitoring of organic pollutants in European surface waters". Sci Total Environ. 635:1620-1621

Tousova, S., Froment, J., Oswald, P., Thomas, K.V., Tollefsen, K.E., Reid, M., Langford, K., Slobodník, J., Hilscherova, K., Blaha, L. (2018) Identification of algal growth inhibitors in treated wastewater using effect-directed analysis based on non-target screening techniques. J. of Maz. Mat., 358: 494-502.

Hiruta, C., Kakui, K., Tollefsen, K.E., Iguchi,T (2018). Targeted gene disruption by use of CRISPR/Cas9 ribonucleoprotein complexes in the water flea Daphnia pulex. Genes to Cells. 23:494-502. doi: 10.1111/gtc.12589.

Altenburger, R., Scholze, M., Busch, W., Escher, B.I., Jakobs, G., Krauss, M., Krüger, J., Neale, P., Ait-Aissa, S., Almeida, A.C., Seiler, T.B., Brion, F., Hilscherova, K., Hollert, H., Novak, J., Schlichting, R., Serra, H., Shao, Y., Tindall, A., Tollefsen, K.E., Umbuzeiro, G., Williams, T., Kortenkamp, A. (2018). Mixture effects in samples of multiple contaminants – An inter-laboratory study with manifold bioassays. Environment International. 114: 95-106.

Song, Y., Asselman, J., De Schamphelaere, K.A.C., Salbu, B., Tollefsen, K.E. (2018). Deciphering the Combined Effects of Environmental Stressors on Gene Transcription: a Conceptual Approach. Environ. Sci. Technol. 52: 5479-5489. doi: 10.1021/acs.est.8b00749.

Gomes, T., Song, Y., Brede, D.A., Xie, L., Gutkzow, K.B., Salbu, B., Tollefsen, K.E. (2018). Gamma radiation induces dose-dependent oxidative stress and transcriptional alterations in the freshwater crustacean Daphnia magna. Sci. Total Environ. 628-629: 206-216. doi: 10.1016/j.scitotenv.2018.02.039.

Xie, L., Gomes, T., Solhaug, K.A., Song, Y., Tollefsen, K.E. (2018). Linking mode of action of the model respiratory and photosynthesis uncoupler 3,5-dichlorophenol to adverse outcomes in Lemna minor. Aquatic Toxicology. 197: 98-108. doi.org/10.1016/j.aquatox.2018.02.005.

Bridges, J., Sauer, U.G., Buesen, R., Deferme, L., Tollefsen, K.E., Tralau, T., van Ravenzwaay, B., Poole, A., Pemberton, M. (2017). Framework for the quantitative weight-of-evidence analysis of ‘omics data for regulatory purposes. Regul Toxicol Pharmacol. 91: S46-S60.

Gant, T.W., Sauer, U.G., Zhang, S.D., Chorley, B.N., Hackermüller, J., Perdichizzi, S., Tollefsen, K.E., van Ravenzwaay, B., Yauk, C., Tong, W., Poole, A. (2017). A generic Transcriptomics Reporting Framework (TRF) for ‘Omics Data Processing and Analysis. Regul Toxicol Pharmacol. 91: S36-S45

Kauffmann, H.M., Fuchs, R., Chorley, B.N., Deferme, L., Ebbels, T., Hackermüller, J., Perdichizzi, S. Poole, A. Sauer, U.G., Tollefsen, K.E., Tralau, T., Yauk, C., van Ravenzwaay, B. (2017). Framework for the quality assurance of ’omics technologies considering GLP requirements. Regul Toxicol Pharmacol. 91: S27-S36

Buesen, R., Chorley, B.N., da Silva Lima, B., Daston, G., Deferme, L., Ebbels, T., Gant. T.W., Goetz, A., Greally, J., Gribaldo, L., Hackermüller, J., Hubesch, B., Jennen, D., Johnson, K., Kanno, J., Kauffmann, H.M., Laffont, M. Meehan, R., Pemberton, M., Perdichizzi1, S., Piersma, A.H., Sauer, U.G., Schmidt, K., Seitz, H., Sumida, K., Tollefsen, K.E., Tong, W., Tralau, T., van Ravenzwaay, B., Weber, R., Worth, A., Yauk, C., Poole, A. (2017). Applying ‘omics technologies in chemicals risk assessment: Report of an ECETOC workshop. Regul Toxicol Pharmacol. 91: S3-S13

Tollefsen, K.E. and Kacew, S. (2017). 6th Norwegian Environmental Toxicology symposium: Assessing and solving environmental challenges in a multiple stressor world. Journal of Toxicology and Environmental Health, Part A. 80 (16-18): 805-806.

Almeida, A.C., Petersen, K., Langford, K., Thomas, K.V. and Tollefsen, K.E. (2017). Mixture toxicity of five biocides with dissimilar modes of action on the growth and photosystem II efficiency of Chlamydomonas reinhardtii. Journal of Toxicology and Environmental Health, Part A. 80 (16-18): 971-986.

Hultman, M.T., Petersen, K., Tollefsen, K.E. (2017). Characterizing combined effects of antiestrogenic chemicals on vitellogenin production in rainbow trout (Oncorhynchus mykiss) hepatocytes. Journal of Toxicology and Environmental Health, Part A. 80 (16-18): 987-1001.

Petersen, K., Hultman, M.T., Bytingsvik, J., Harju, M., Evenset, A., Tollefsen, K.E. (2017). Characterizing cytotoxic and estrogenic activity of Arctic char tissue extracts in primary Arctic char hepatocytes. Journal of Toxicology and Environmental Health, Part A. 80 (16-18): 1017-1030.

Song, Y., Evenseth, L.M., Iguchi, T., Knut Erik Tollefsen (2017). Release of chitobiase as an indicator of potential molting disruption in juvenile Daphnia magna exposed to ecdysone receptor agonists Journal of Toxicology and Environmental Health, Part A. 80 (16-18): 954-962.

Tollefsen, K.E., Song, Y., Høgåsen, T., Øverjordet, I.B., Altin, D., Hansen, B.H. (2017). Acute and sublethal toxicity of mercury to the marine copepod Calanus finmarchicus. J. Toxicol. Environ Health A. 80 (16-18): 845-861.

Petersen, K., Hultman, M.T., Rowland, S., Tollefsen, K.E. (2017). Toxicity of organic compounds from unresolved complex mixtures (UCMs) to primary fish hepatocytes. Aquatic Toxicology. 190:150-161.

Tousova, Z, Oswald, P., Slobodnik, J., Muz, M., Hu, H., Brack, W., Krauss, M., Koprivica, S., Ahel, M., Schollee, J., Hidasi, A., Hollender, J., Schirmer, K-, Suter, M.J.F., Sonavane, M., Ait-Aissa, S:, Creusot, N., Brion, F., Di Paolo, C., Seiler, T.B., Hollert, H., Froment, J., Almeida, A.C., Thomas, K.V., Tollefsen, K.E., m Tufi, S., Ouyang, X., Leonards, P., Lamoree, M., Torrens, V.O., Schriks, M., Kolkman, A.M., Spirhanzlova, P., Tindall, A., Blaha, L., Schulze, T. (2017).  EDA-EMERGE – European demonstration program on the effect-based and chemical identification and monitoring of organic pollutants with adverse effect potential in European surface waters. Sci. Total. Environ. 601-602: 1849-1868.

Almeida, A.C., Gomes, T. Langford, K., Thomas, K.V., Tollefsen, K.E. (2017). Oxidative stress in the algae Chlamydomonas reinhardtii exposed to biocides. Aquatic Toxicology. 189: 50-59.

Brockmeier, E., Hodges, G., Hutchinson, T.H., Butler, E., Hecker, M., Tollefsen, K.E., Garcia-Reyero, N., Kille, P., Becker, D., Chipman, K., Colbourne, J., Collette, T., Cossins, A., Cronin , M., Graystock, P., Gutsell, S., Knapen, D., Katsiadaki, I., Lange, A., Marshall, S. Owen, S., Perkins, E.J., Plaistow, S., Schroeder, A:, Taylor, D., Viant, M., Ankley, G., Falciani, F. (2017). The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment. Toxicological Sciences. 158 (2): 252-262. doi: 10.1093/toxsci/kfx097.

Neale, P. A., Altenburger, R., Ait-Aissa, S., Brion, F., Busch, W., de Aragao Umbuzeiro, G., Denison, M. S., Du Pasquier, D. Hilscherova, K., Hollert, H., MPlatformes, D. A. Novak, J. ., Schlichting, R. . Seiler, T. B., Serra, H., Shao, Y., Tindall, A. J., Tollefsen, K. E. Williams, T. D.  and B. I. Escher (2017). Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their contribution to effects in surface water, Water Res, 123: 734-50.

Fay, K.A., Villeneuve, D.L., Lalone, C.A. Song, Y., Tollefsen, K.E., Ankley, G.T. (2017).  Practical approaches to adverse outcome pathway (AOP) development and weight of evidence evaluation as illustrated by ecological case studies. Environ. Toxicol. Chem. 36(6):1429-1449.

Song, Y., Villeneuve, D.; Toyota, K.; Iguchi, T., Tollefsen, K.E.  (2017). Ecdysone Receptor Agonism Leading to Lethal Molting Disruption in Arthropods: Review and Adverse Outcome Pathway Development. Environ. Sci. Technol., Critical reviews. 51 (8): 4142–4157

Petersen, K., Hultman, M., Tollefsen, K.E. (2017). Primary hepatocytes from Arctic char (Salvelinus alpinus) as an environmentally relevant Arctic in vitro model for screening contaminants and environmental extracts. Aquatic toxicology.187: 141–152.

Schulze, T., Ahel, M., Ahlheim, J., Aït-Aïssa, S., Brion, F., Di Paolo, C., Froment, J., Hidasi, A.O., Hollender, J., Hollert, H., Hu, M., Kloß, A., Koprivica, S., Krauss, M., Muz, M., Petre, M., Oswald, P., Schollée; J.E. Seiler, T.B., Shao, Y., Slobodnik, J., Sonavane, M., Suter, M., Tousova, Z., Tollefsen, K.E., Walz, K.H., Brack, W. (2017). Assessment of a novel device for onsite integrative large-volume solid phase extraction of water samples to enable a comprehensive chemical and effect-based analysis. Sci. Total Environment. 581-582: 350–358.

Ouyang, X., Froment, J., Leonards, P. E.G., Christiensen, G., Tollefsen, K.E., de Boer, J., Thomas, K.V., Lamoree, M.H. (2017). Miniaturization of a transthyretin binding assay using a fluorescent probe for high throughput screening of thyroid hormone disruption in environmental samples. Chemosphere. 171: 722–728.

Gomes, T., Xie, L., Brede, D., Lind, O.C., Solhaug, K.A., Salbu, B., Tollefsen, K.E. (2017). Sensitivity of the green algae Chlamydomonas reinhardtii to ionizing (gamma) radiation: photosynthetic performance and ROS formation. Aquatic Toxicology. 183:1-10.

Bender, M.L., Frantzen, M., Vieweg, I., Falk-Petersen, I.B., Johnsen, H.K., Rudolfsen, G., Tollefsen, K.E., Dubourg, P. and Nahrgang, J. (2016).  Effects of chronic dietary petroleum exposure on reproductive development in polar cod  (Boreogadus saida). Aquatic Toxicology. 180: 196-208.

Song, Y., Rundberget, J.T., Evenseth, L., Xie, L. Gomes, T., Høgåsen, T. Iguchi, T. Tollefsen, K.E. (2016). Whole-organism transcriptomic analysis provides mechanistic insight into the acute toxicity of emamectin benzoate in Daphnia magna. Environ. Science Technol. 50(21):11994-12003.

Song, Y., Salbu, B., Teien, H.C., Evensen, Ø. Lind, O.C., Rosseland, B.O., Tollefsen, K.E. (2016).  Hepatic transcriptional responses in Atlantic salmon (Salmo salar) exposed to gamma radiation and depleted uranium singly and in combination. Sci Total Environment. 562:270-9.

Froment, J., Thomas, K., Tollefsen, K.E.  (2016). Automated high-throughput in vitro screening of the acetylcholine esterase inhibiting potential of environmental samples, mixtures and single compounds. Ecotoxicol. Environ. Safety. 215, 18-26.

Jensen, L.K., Halvorsen, E., Song, Y., Hallanger, I.G., Hansen, E.L. Brooks, S.,  Hansen, B.H., Tollefsen, K.E. (2016). Individual and molecular level effects of produced water contaminants on nauplii and adult females of Calanus finmarchicus. J. Toxicol. Environ Health A. 79 (13-15), 585-601

Froment, J. Langford, K., Tollefsen, K.E., Nerland, I.L. Brooks, S.J. Thomas, K.V. (2016). Identification of petrogenic produced water components as acetylcholine esterase inhibitors. Environmental Pollution. 215: 18-26.

Tollefsen, K.E., Song, Y., Kleiven, M., Mahrosh, U., Meland, S., Rosseland, B.O., Teien, H.C. (2015) Transcriptional changes in Atlantic salmon (Salmo salar) after embryonic exposure to road salt. Aquatic Toxicology. 169:58-68

Hultman, M., Song, Y., Tollefsen, K.E. (2015). 17α-Ethinylestradiol (EE2) effect on global gene expression in primary rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquatic Toxicology. 169:90-104

Groh, K., and Tollefsen, K.E. (2015). The Challenge: Adverse outcome pathways in research and regulation—Current status and future perspectives. Environ. Toxicol. Chem. 34: 1935-1936.

Muusse, M., Christensen, G., Gomes, T. Kocan, A., Tollefsen, K.E., Vankova, L., Thomas, K.V. (2015). Characterization of AhR agonists in European herring gull eggs. Sci. Total. Environ. 514: 211–218.

Altenburger, R., Ait-Aissa, S., Antczak, P., Backhaus, T., Barceló, D., Seiler, T-B; Brion, F., Busch, W., Chipman, K., López de Alda, M., de Aragão Umbuzeiro, G., Escher, B.I., Falciani, F., Faust, M., Focks, A., Hilscherova, K., Hollender, J., Hollert, H., Jäger, F., Jahnke, A., Kortenkamp, A., Krauss, M., Lemkine, G.F., Munthe, J. Neumann, S., Schymanski, E.L., Scrimshaw, M., Segner, H., Slobodnik, J., Smedes, F., Subramaniam, K., Teodorovic, I., Tindall, A.J., Tollefsen, K.E., Walz, K-H. Williams, T.D., Van den Brink, P.J., van Gils, J., Vrana, B, Zhang, X. (2015). Future water quality monitoring - Adapting tools to deal with mixtures of pollutants in water resource management. Sci. Total Environ. 512-513: 540-551. ISBN: 1879-1026.

Abe, R, Toyota, K., Miyakawa, H., Watanabe,H., Okad, T., Miyagaw, S. Nishide, H., Uchiyamae, I., Tollefsen, K.E., Iguchi, T., Tatarazakoa, N. (2015) Diofenolan induces male offspring production through binding to the juvenile hormone receptor in Daphnia magna. Aquatic toxicology.159: 44-51

Hultman, M.T., Rundberget, J.T., Tollefsen, K.E. (2015). Evaluation of vitellogenin induction in rainbow trout (Oncorhynchus mykiss) hepatocytes as a screening assay for estrogen mimics. Aquatic Toxicol. 159: 233-44. ISBN: 1879-1514

Brack, W., Altenburger, R., Schuurmann, G., Krauss, M., Lopez Herraez, D., van Gils, J., Slobodnik, J., Munthe, J., Gawlik, B.M., van Wezel, A., Schriks, M., Hollender, J., Tollefsen, K.E., Mekenyan, O., Dimitrov, S., Bunke, D., Cousins, I., Posthuma, L., van den Brink, P.J., Lopez de Alda, M., Barcelo, D., Faust, M., Kortenkamp, A., Scrimshaw, M., Ignatova, S., Engelen, G., Massmann, G., Lemkine, G., Teodorovic, I., Walz, K.H., Dulio, V., Jonker, M.T., Jager, F., Chipman, K., Falciani, F., Liska, I., Rooke, D., Zhang, X., Hollert, H., Vrana, B., Hilscherova, K., Kramer, K., Neumann, S., Hammerbacher, R., Backhaus, T., Mack, J., Segner, H., Escher, B., de Aragao Umbuzeiro, G., (2015). The SOLUTIONS project: Challenges and responses for present and future emerging pollutants in land and water resources management. Sci Total Environ. 503-504: 22-31. Doi: 10.1016/j.scitotenv.2014.05.143.

Song, Y., Salbu, B., Teien, H.C., Heier, L.S., Rosseland, B.O., Høgåsen, T., Tollefsen, K.E. (2014). Global transcriptional analysis of short-term hepatic stress responses in Atlantic salmon (Salmo salar) exposed to depleted uranium. Data in brief. Genomics data. 2: 340-341.

Tollefsen, K.E., Scholz, S., Cronin, M.T.C., Edwardsd, S.C., de Knecht, J., Crofton, K., Garcia-Reyero, N., Hartung, T., Worth, A. Patlewiczi, G. (2014). Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA). Reg Tox Pharm. 70(3): 629-640.doi: 10.1016/j.yrtph.2014.09.009. ISBN:1096-0295.

Rodriguez-Sanchez, N., Cronin, M.T.D., Lillicrap, A., Madden, J.C., Piechota, P., Tollefsen, K.E. (2014). Development of a list of reference chemicals for evaluating alternative methods to in vivo fish bioaccumulation tests. Environ. Tox. Chem. 33 (12): 2740-2752. ISBN: 1552-8618

Song, Y., Salbu, B., Teien, H.C., Heier, L.S., Rosseland, B.O., Tollefsen, K.E. (2014). Dose-dependent hepatic transcriptional responses in Atlantic salmon (Salmo salar) exposed to sublethal doses of gamma radiation. Aquatic Toxicology. 156: 52-64.

Song, Y., Salbu, B., Teien, H.C., Heier, L.S., Rosseland, B.O., Høgåsen, T., Tollefsen, K.E.

(2014). Hepatic transcriptomic profiling reveals early toxicological mechanisms of uranium in Atlantic salmon (Salmo salar). BMC Genomics.  15: 694-713. DOI: 10.1186/1471-2164-15-694.

Mommens, M., Fernandes, J., Tollefsen, K.E., Johnston, I.A., Babiak, I. (2014). Profiling of the embryonic Atlantic halibut (Hippoglossus hippoglossus L.) transcriptome reveals maternal transcripts as potential markers of embryo quality. BMC Genomics.15: 829-842.

Petersen, K., Heiaas, H., Tollefsen, K.E. (2014). Combined effects of pharmaceuticals, personal care products, biocides and organic contaminants on the growth of Skeletonema pseudocostatum. Aquatic Toxicology. 150: 45-54.

West, C.E., Scarlett, A., Tonkin, A., O’Carroll-Fitzpatrick, D., Pureveen, J., Tegelaar, E., Gieleciak, R., Hager, D., Petersen, K., Tollefsen, K.E., Rowland, S.J. (2014). Diaromatic sulfur-containing ‘naphthenic’acids in process waters. Water Research. 51: 206-15.
Muusse, M., Christensen, G., Langford, K., Tollefsen, K.E., Thomas, K.V. (2014). Aryl hydrocarbon receptor agonists in European Herring Gull (Larus argentatus) eggs from Norway. J. Toxicol. Environ. Health, Part A: Current Issues, 77:9-11, 550-556, DOI: 10.1080/15287394.2014.887419.
Farmen, E., Hultman, M.T., Anglès d'Auriac, M., Tollefsen, K.E. (2014) Development of an aquatic in vitro screening system for determination of potential DNA methylation alterations relevant to ecotoxicology. J. Toxicol. Environ. Health, Part A: Current Issues, 77:9-11, 587-599, DOI: 10.1080/15287394.2014.887423
Carlsson, G., Norrgren L., Hylland, K. and Tollefsen, K.E. (2014). Are organic compounds in effluents from oil production platforms toxic to fish embryos?. J. Toxicol. Environ. Health, Part A: Current Issues, 77:9-11, 600-615., DOI: 10.1080/15287394.2014.887424

Beyer, J., Petersen, K., Song, Y., Ruus, A., Grung, M. Bakke, T., Tollefsen, K.E. (2014). Environmental risk assessment of combined effects in aquatic ecotoxicology: a discussion paper. Mar. Environ. Res. 96: 81-91

Scholz, S.,  Sela, E., Blaha, L-, Braunbeck, T., Galay-Burgos, M., García-Franco, M., Guinea, J., Klüver, N., Schirmer, K., Tanneberger, K., Tobor-Kapłon, M., Witters, H., Belanger, S., Benfenati, E., Creton, S., Cronin, M.T.D., Eggen, R.I.L., Embry, M., Ekman, D., Gourmelon, A., Halder, M. Hardy, B., Hartung, T., Hubesch, B., Jungmann, D., Lampi, M.A., Lee, L., Léonard, M., Küster, E. Lillicrap, A., Luckenbach, T., Murk, A.J., Navas, J.M., Peijnenburg, W., Repetto, G., Salinas, E., Schüürmann, G., Spielmann, H., Tollefsen, K.E., Walter-Rohde, S:, Whale, G., Wheeler, J.R. and Winter, M.J., (2013). A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment. Regulatory Toxicology and Pharmacology, 67: 505-530. ISBN:1096-0295.

Petersen, K.E., Fetter, E., Kah, O., Brion, F., Scholz, S., Tollefsen, K.E. (2013) Transgenic (cyp19a1b-GFP) zebrafish embryos as a tool for assessing combined effects of oestrogenic chemicals. Aquatic. Toxicol. 138-139: 88-97.

Smital, T., Terzic, S., Loncar, J., Senta, I., Zaja, R., Popovic, M., Mikac, I., Tollefsen, K.E., Thomas, K.V., Ahel, M., (2013). Prioritisation of organic contaminants in a river basin using chemical analyses and bioassays. Environ Sci Pollut Res Int. 20:1384-95

Heier, L.S., Teien, H.C., Oughton, D., Tollefsen, K.E., Olsvik, P., Rosseland, B.O., Lind, O.K., Skipperud, L., Finne, E.F., Salbu, B. (2013). Sublethal effects in Atlantic salmon (Salmo salar) exposed to mixtures of copper, aluminium and gamma radiation. J. Environ. Radioact. 121: 33-42.

Tollefsen, K.E., Nizzetto, L., Huggett, D.B. (2012). Presence, fate and effects of the intense sweetener sucralose in the aquatic environment. Sci. Total. Environ. 438: 510-516.

Muusse, M., Langford, K., Tollefsen, K.E., Cornelissen, G., Haglund, P., Hylland, K., Thomas, K.V. (2012). Characterization of AhR agonist compounds in road-side snow. Analyt. Bioanalytic. Chem. 403: 2047-56

Tollefsen, K.E., Petersen, K., Rowland, S.J. (2012). Toxicity of synthetic naphthenic acids and mixtures of these to fish liver cells. Environ. Sci. Technol.  46: 5143-5150.

Song, Y., Salbu, B., Heier, L.S., Teien, H.C., Lind, O.K., Oughton, D., Petersen, K., Rosseland, B.O., Skipperud, L., Tollefsen, K.E. (2012). Early stress responses in Atlantic salmon (Salmo salar) exposed to environmentally relevant concentrations of uranium. Aquatic Toxicol. 112-113:62-71.

Petersen, K. and Tollefsen, K.E. (2012). Combined effects of estrogen receptor antagonists on in vitro vitellogenesis. Aquatic. Toxicol. 112-113C:46-53.

Holth, T.F. and Tollefsen, K.E. (2012). Organic chemicals in effluents from oil production platforms in the North Sea modulate fish Acetylcholine Esterase activity in vitro. Aquatic Toxicology. 112-113: 92-98.

Beyer, J., Myhre, L.P., Sundt, R.C., Meier, S., Tollefsen, K.E., Vabø, R., Klungsøyr, J., Sanni, S. (2012). Environmental risk assessment of alkylphenols from offshore produced water on fish reproduction. Marine environmental Research. 75: 2-9.

Farmen, E.; Mikkelsen, H.N.; Evensen, Ø.; Einset, J.; Heier, L.S.; Rosseland, B.O.; Salbu, B.; Tollefsen, K.E.; Oughton, D.H. (2012). Acute and sub-lethal effects in juvenile Atlantic salmon exposed to low μg/L concentrations of Ag nanoparticles. Aquatic Toxicology.  108: 78-84.

Smital, T., Terzić, S., Žaja, R., Senta, I., Pivčević, B., Popović, M., Mikac, I., Tollefsen, K.E., Thomas, K.V., Ahel, M. (2011).  Assessment of toxicological profiles of the municipal wastewater effluents using chemical analyses and bioassays. Ecotoxicol. Environ. Safety. 74: 844-851.

Meland, S. Farmen, E., Heier, L.S., Rosseland, B.O., Salbu, B., Tollefsen, K.E. (2011). Hepatic gene expression profile in brown trout (Salmo trutta) exposed to traffic related contaminants. Sci. Total Environ. 409: 1430-1443.

Thomas, K.V., Farkas, J., Gregersen, I.K., Finne, E.F. Christian, P., Langford, K., Norby, P., Tollefsen, K.E. (2011). Effects of dispersed aggregates of carbon and titanium dioxide engineered nanoparticles on rainbow trout hepatocytes. J. Toxicol. Environ. Health 74, 466-477

Tollefsen, K.E., Sundt, R.C., Beyer, J., Meier, S., Hylland, K. (2011). Endocrine modulation in Atlantic cod (Gadus morhua L.) exposed to alkylphenols, PAHs, produced water and dispersed oil. J. Toxicol. Environ. Health 74, 529-542.

Lillicrap, A., Langford, K., Tollefsen, K.E. (2011). Bioconcentration of sucralose in a multitrophic battery of aquatic organisms Environ. Toxicol. Chem.30: 673-681.

Skjelbred, B., Horsberg, T.E., Tollefsen, K.E., Andersen, T., Edvardsen, B. (2011), Toxicity of the ichthyotoxic marine flagellate Pseudochattonella (Dictyochophyceae; Heterokonta) assessed by six bioassays, Harmful Algae 10: 144-154.

Farkas, J., Christian, P., Gallego-Urrea, J. A., Roos, N., Hassellov, M., Tollefsen, K. E. and Thomas, K. V. (2011). Uptake and effects of manufactured silver nanoparticles in rainbow trout (Oncorhynchus mykiss) gill cells. Aquat Toxicol 101, 117-125.

Petersen, K. and Tollefsen, K.E. (2011). Assessing combined toxicity of estrogen receptor agonists in a primary culture of rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquatic. Toxicol. 101:186-195.

Johnsen, T.M., Eikrem, W., Olseng, C.D., Tollefsen, K.E., Bjerknes, V. (2010). Prymnesium Parvum: The Norwegian experience. J. Am. Water Res. Ass. 46:6-13

Meland, S., Heier, L., Tollefsen, K.E., Salbu, B., Rosseland, B.O. (2010). Exposure of brown trout (Salmo trutta L.) to tunnel wash water runoff – chemical characterisation and biological impact. Sci. Total Environ. 408: 2646-2656

Farkas, J., Christian, P., Urrea, J. A., Roos, N., Hassellov, M., Tollefsen, K. E., Thomas, K. V. (2010). Effects of silver and gold nanoparticles on rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquatic Toxicol. 96:44-52

Ellesat, K.S., Tollefsen, K.E., Åsberg, A., Thomas, K., Hylland, K. (2010). Cytotoxicity of atorvastatin and simvastatin on primary rainbow trout (Oncorhynchus mykiss) hepatocytes. Toxicol. in Vitro. 24:1610-1618.

Farmen, E.F., Harman, C., Hylland, K., Tollefsen, K.E. (2010). Produced water extracts from oil and gas production platforms in the North Sea produce oxidative stress in a rainbow trout toxicity bioassay. Mar. Poll. Bull.60: 1092-1098.

Harman, C., Finne, E.F., Tollefsen, K.E. (2010). Monitoring North Sea oil production discharges using passive sampling devices coupled with in vitro bioassay techniques. J. Environ. Monitor. 12: 1699-1708.

Brix, R., Noguerol, T. N., Piña, B., Balaam, J., Nilsen, A.J., Tollefsen, K.E., Levy, W., Schramm, K.W., Barceló, D. (2010). Evaluation of the suitability of recombinant yeast-based estrogenicity assays as a pre-screening tool in environmental samples. Environ. International. 36:361-367.

Farmen, E. F., Olsvik, P. A., Berntssen, M.H.G., Hylland, K., Tollefsen, K.E. (2010). Oxidative stress responses in rainbow trout hepatocytes exposed to pro-oxidants and a complex environmental sample. Comp. Biochem. Physiol. Part C151, 431-438.

Berntssen, M.H.G. Tollefsen, K.E., Handy, R.C., Julshamn, K., Aasen, K., Helland, E., Petri, D. (2010). Assessing sensitivity of Atlantic salmon post smolt to dietary endosulfan using histology and markers of endocrine disruption, oxidative stress, and biotransformation. Aquaculture.303, 86-93.

Haukås, M., Mariussen, E., Ruus, A., Tollefsen, K.E. (2009). Accumulation and disposition of hexabromocyclododecane (HBCD) in juvenile rainbow trout (Oncorhynchus mykiss). Aquatic Toxicol. 95, 144-151.

Harman, C., Thomas, K.V., Tollefsen, K.E., Meier, S., Bøyum, O., Grung, M. (2009) Monitoring the freely dissolved concentrations of polycyclic aromatic hydrocarbons (PAH) and alkylphenols (AP) around a Norwegian oil platform by holistic passive sampling. Marine Pollution Bulletin. 58, 1671–1679

Thomas , K.V., Langford, K., Petersen, Smith, A.J., Tollefsen, K.E. (2009). Effect-directed identification of naphthenic acids as important in vitro xeno-estrogens and anti-androgens in North Sea offshore produced water discharges. Environ. Sci. Technol. 43: 8066-8071.

Melbye, A.G:, Brakstad, O.G., Hokstad, J.N., Gregersen, I.K., Hansen, B.H., Booth, A.B., Rowland, S.J., Tollefsen, K.E. (2009). Chemical and toxicological characterisation of an unresolved complex mixture (UCM)-rich biodegraded crude oil. Environ. Toxicol. Chem.28: 1815-1824

Goksøyr, A., Tollefsen, K.E., Grung, M., Løken, K., Lie, E., Zenker, A., Fent, K., Schlabach, M., Huber, S. (2009). Balsa raft crossing the Pacific finds low contaminant levels. Environ. Sci. Technol.43: 4783-4790.

Heier, L.S., Lien, I., Strømseng, A.E., Ljønes, M., Rosseland, B.O., Tollefsen, K.E., Salbu, B. (2009). Speciation of lead, copper, zinc and antimony in water draining a shooting range -  time dependant metal accumulation and biomarker responses in brown trout (Salmo trutta L). Sci. Total Environ.407: 4047-4055

Finne E.F, Olsvik, P.A., Berntssen, M.H.G., Hylland, K., Tollefsen, K.E. (2008).  The partial pressure of oxygen affects biomarkers of oxidative stress in cultured rainbow trout (Oncorhynchus mykiss) hepatocytes. Toxicol. In vitro. 22: 1657-1661.

Tollefsen, K. E., Eikvar, S., Finne, E. F., Fogelberg, O., Gregersen, I. K. (2008). Estrogenicity of alkylphenols and alkylated non-phenolics in a rainbow trout (Oncorhynchus mykiss) primary hepatocyte culture. Ecotoxicol. Environ. Saf. 71: 370-383.

Harman, C., Tollefsen, K-E., Bøyum, O., Thomas, K.V. and Grung, M. (2008). Uptake rates of alkylphenols, PAHs and carbazoles in semipermeable membrane devices (SPMDs) and polar organic chemical integrative samplers (POCIS). Chemosphere 72: 1510-1516.

Pivèev, B., Smital, T., Tollefsen, K.E. (2008). Effluents from oil production platforms in the north sea inhibit the function of the abc transporters mdr1 and mrp1 in vitro. Marine Environmental Research 66(1): 82-82

Hylland, K., Tollefsen, K. E., Ruus, A., Jonsson, G., Sundt, R. C., Sanni, S., Utvik, T. I. R., Johnsen, S., Nilssen, I., Pinturier, L., Balk, L., Baršienė, J., Marigòmez, I., Feist, S., Børseth, J. F. (2008). Water column monitoring near oil installations in the North Sea 2001-2004. Mar. Pollut. Bull. 56: 414-29

Källqvist, T., Milačič, R., Smital, T., Thomas, K. V., Vranes, S. and Tollefsen, K. E. (2008). Chronic toxicity of the Sava river (SE Europe) sediments and river water to the algae Pseudokirchneriella subcapitata. Water Res. 42: 2146-2156.

Harman, C., Bøyum, O., Tollefsen, K., Thomas, K.V. and Grung, M. (2008). Uptake of some selected aquatic pollutants in semipermeable membrane devices (SPMDs) and the polar organic chemical integrative sampler (POCIS). J. Env. Monit. 10, 239-247.

Tollefsen, K. E. and Nilsen, A. J. (2008). Binding of alkylated phenols and non-phenolics to the hepatic estrogen receptor in rainbow trout (Oncorhynchus mykiss). Ecotox. Environ. Saf. 69: 163-172.

Tollefsen, K. E., Blikstad, C., Eikvar, S., Finne, E.F., Gregersen, I.K (2008).

Cytotoxicity of alkylphenols and alkylated non-phenolics in a primary culture of rainbow trout (Onchorhynchus mykiss) hepatocytes. Ecotoxicol. Environ. Saf. 69: 64-73.

Glover, C. N., Petri, D., Tollefsen, K. E., Jørum, N., Handy, R. D., Berntssen, M.H.G. (2007). Assessing sensitivity of Atlantic salmon (Salmo salar) to dietary endosulfan exposure using tissue biochemistry and histology. Aquat. Toxicol. 84: 346-355.

Finne, E. F., Cooper, G. A., Koop, B. F., Hylland, K. and Tollefsen, K. E. (2007). Toxicogenomic responses in rainbow trout (Oncorhynchus mykiss) hepatocytes exposed to model chemicals and a synthetic mixture. Aquat. Toxicol .81: 293-303.

Tollefsen, K.E. (2007). Binding of alkylated phenols and non-phenolics to the rainbow trout (Oncorhynchus mykiss) plasma sex steroid-binding protein. Ecotoxicol. Environ Safety. 68: 40-48

Tollefsen, K.E., Harman, C., Smith, A. and Thomas, K.V. (2007). Estrogen receptor (ER) agonists and androgen receptor (AR) antagonists in effluents from Norwegian North Sea oil production platforms. Mar. Poll. Bull. 54: 277-283.

Grung, M., Lichtenthaler, R., Ahel, M., Tollefsen, K.E., Langford, K. and Thomas, K.V. (2007) Effects-directed analysis of organic toxicants in wastewater effluent from Zagreb, Croatia. Chemosphere. 40: 108-120.

Vogelsang, C., Grung, M., Jantsch, T.G., Tollefsen, K.E. and Helge Liltved (2006). Occurrence and removal of selected organic micropollutants at mechanical, chemical and advanced wastewater treatment plants in Norway. Water Res. 40: 3559-3570.

Olsvik, P.A., Kristensen, T., Waagbo, R.,Tollefsen, K.E., Rosseland, B.O. and Toften, H. (2006). Effects of hypo- and hyperoxia on transcription levels of five stress genes and the glutathione system in liver of Atlantic cod Gadus morhua. J. Exp. Biol. 209: 2893-2901.

Tollefsen, K. E., Bratsberg, E., Bøyum, O., Finne, E. F., Gregersen, I. K., Hegseth, M. N., Sandberg, C. and Hylland, K. (2006). Use of fish in vitro hepatocyte assays to detect multi-endpoint toxicity in Slovenian River sediments. Mar. Environ. Res. 62: S356-S359.

Tollefsen, K. E., Finne, E. F., Romstad, R. and Sandberg, C. (2006). Effluents from oil production activities contain chemicals that interfere with normal function of intra- and extra-cellular estrogen binding proteins. Mar. Environ. Res. 62: S191-S194.

Källqvist, T., Grung, M. and Tollefsen, K.E. (2006). Chronic toxicity of 2,4,2’,4’ tetrabromodiphenylether (BDE-47) on the marine alga Skeletonema costatum and the crustacean Daphnia magna. Environ. Toxicol. Chem. 25: 1657-1662.

Olsen, C.M., Meussen-Elholm, E.T.M., Hongslo, J.K., Stenersen, J. and  Tollefsen, K.-E. (2005). Estrogenic effects of environmental chemicals: an interspecies comparison. Comp. Biochem. Physiol.C 141, 267-274.

Olsvik, P. A., Kristensen, T., Waagbø, R., Rosseland, B. O., Tollefsen, K.-E., Baeverfjord, G. and Berntssen, M. H. G. (2005). mRNA expression of antioxidant enzymes (SOD, CAT and GSH-Px) and lipid peroxidative stress in liver of Atlantic salmon (Salmo salar) exposed to hyperoxic water during smoltification. Comp. Biochem. Physiol.C 141, 314-323

Tollefsen, K.E., Ovrevik, J. and Stenersen, J. (2004). Binding of xenoestrogens to the sex steroid-binding protein in plasma from Arctic charr (Salvelinus alpinus L.). Comp. Biochem. Physiol. C 139, 127-133

Tollefsen, K.-E., Mathisen, R. & Stenersen, J. (2003). Induction of vitellogenin synthesis in an Atlantic salmon (Salmo salar) hepatocyte culture: a sensitive in vitro bioassay for the oestrogenic and anti-oestrogenic activity of chemicals. Biomarkers. 8: 394-407.

Tollefsen, K.-E., Meyes, J.F.A. Frydenlund, J. & Stenersen, J. (2002) Environmental estrogens interact with and modulate the properties of plasma sex steroid-binding proteins in Atlantic salmon (Salmo salar). Mar. Environ. Res. 54: 697-701.

Tollefsen, K.-E., Mathisen, R & Stenersen, J. (2002) Estrogen mimics bind with similar affinity and specificity to the hepatic estrogen receptor in Atlantic salmon (Salmo salar) and rainbow trout (Oncorhynchus mykiss). Gen. Comp. Endocrinol. 126:14-22.

Tollefsen, K.-E. (2002) Interaction of estrogen mimics, singly and in combination, with plasma sex steroid-binding proteins in rainbow trout (Oncorhynchus mykiss). Aquat. Toxicol. 56: 215-22.

Øvrevik, J., Stenersen, J., Nilssen, K. & Tollefsen, K.-E. (2001) Partial Characterization of a sex steroid-binding protein in plasma from Arctic charr (Salvelinus alpinus L.). Gen. Comp. Endocrinol. 121: 31-39.

Tollefsen, K-E., Ingebrigtsen, K., Olsen, A.J., Zachariassen, K.E. & Johnsen, S. (1998) Acute toxicity and toxicokinetics of 4-heptylphenol in juvenile Atlantic cod (Gadus morhua L.) Environ. Toxicol. Chem. 17:740-746            

Knudsen, F.R., Schou, A., Wiborg, M.L., Mona, E., Tollefsen, K.E., Stenersen, J.V.  & Sumpter, J.P. (1997) Increase in plasma vitellogenin in rainbow trout (Oncorhynchus mykiss) exposed to effluents from oil refinery treatment works and municipial sewage. Bull. Environ. Contam. Toxicol. 59: 802-806.

Peer-reviewed special publication series (Total: 4)

Tollefsen, K. E. and Thomas, K. V. (2006). Endocrine disrupters in the aquatic environment. In "Endocrine Disrupting Chemicals" (Grotmol, T., Bernhoft, A., Eriksen, G. S. and Flaten, T. P., Eds.). The Norwegian Academy of Science and Letters, Oslo. Pp. 14-24

Ruus, A., Tollefsen, K.-E., Grung, M., Klungsøyr, J. and Hylland, K. (2006). Accumulation of contaminants in pelagic organisms, caged blue mussels, caged cod and semi-permeable membrane devices (SPMDs). In: Biological effects of contaminants in marine pelagic ecosystems (Hylland, K., Lang, T., Vethaak, D, eds.). SETAC Press, Brussels. Pp. 51-74.

Scott, A., Kristiansen, I., Katsiadaki, I., Thain, J., Tollefsen, K.-E., Goksøyr, A. and Barry, J. (2006). Assessment of oestrogen exposure in cod (Gadus morhua) and saithe (Pollachius virens) in relation to their proximity to an oil field. In: Biological effects of contaminants in marine pelagic ecosystems (Hylland, K., Lang, T.,Vethaak, D, eds.). SETAC Press, Brussels. Pp. 329-339.

Tollefsen, K.-E., Goksøyr, A. and Hylland, K., (2006). Assessment of cytotoxic, CYP1A inducing and oestrogen activity in waters from the German Bight and the Statfjord area of the North Sea by a suite of fish in vitro bioassays. In: Biological effects of contaminants in marine pelagic ecosystems (Hylland, K., Lang, T., Vethaak, D, eds.). SETAC Press, Brussels. Pp. 385-395.

International reports/workshops/symposia/Books (Total: 20)

Mellor, C.L.,  Cronin, M.T.,  Evenseth, L.M.,  Sylte, I.,  Kristiansen, K., Tollefsen, K.E. (2014). Integrating Computational Modelling of Receptor Binding into Mechanistically-Based Risk Assessment for Endocrine Disruptors. Toxicology Letters 229, Supplement(0): S162-S163. http://dx.doi.org/10.1016/j.toxlet.2014.06.559.

Munn, S., Goumenou, M. (2013). Key scientific issues relevant to the identification and characterisation of endocrine disrupting substances. Report of the Endocrine Disrupters Expert Advisory Group (ED EAG). 2013, p. 34. (Contributed as EAG participant)

Klamer, H. J., Tollefsen, K.E., Brooks, S., Thain, J. (2012). Protocols for extraction, clean-up, and solvent-exchange methods for small scale bioassays. ICES Cooperative research report No. 315, Nov. 2012. Copenhagen, Denmark. pp 165-73.

Harman, C., Brooks, S., Allan, I., Thomas, K., Tollefsen, K.E., Grung, M. (2011). Passive Sampling Methods for the Measurement of Organic Chemical Contamination from the Offshore Oil Industry. Proceedings, the 6th international conference on remediation of contaminated sediments (New Orleans, LA; February 7–10, 2011). Paper B-51.

Finne, E.F., Olsvik, P.A. Berntssen, M.H.G., Hylland, K. and Tollefsen, K.E. (2006). Oxidative stress and cellular damage in rainbow trout hepatocytes exposed to single chemicals and environmental extracts.  Mar. Environ. Res. 62, S443-S444.

Hylland, K., Tollefsen, K.E., Källqvist, T., Ruus, A., Bøe, E., Schaanning, M., Olsgard, F. (2006). Understanding sediment toxicity – Tools, environmental factors and interactions. Mar. Environ. Res. 62, S367-S367

Brix, R., Piña, B., Balaam, J., Tollefsen, K.E., Schramm, K.-W. and Barceló, D. (2006). Inter-comparison of estrogenicity in water with determined by yeast-based assays. Sub-project report from the EU-STREP “SWIFT” pp. 17.

Sandberg, C., Finne, E.F., and Tollefsen, K.E. (2006). Gene expression of biomarkers for estrogens and CYP1A inducers in rainbow trout (Onchorhynchus mykiss) hepatocytes. Mar. Environ. Res. 62, S396-S397.

Klamer, H. J., Thomas, K. V. and Tollefsen, K. E. (2005). Extraction procedures applicable to small-scale bioassays.  ICES WGBEC report 2005, Copenhagen, Denmark. pp 86-92.  

Tollefsen, K.-E. (2001) Interaction of environmental estrogens with fish extra- and intracellular high-affinity estrogen binding proteins: implications for the reproductive physiology of fish. Ph.D thesis defended for the Dr. scient degree at the Unversity of Oslo (Norway). University of Oslo, 26. april 2001.

Hylland, K., Bøe, E., Ruus, A., Tollefsen, K.E., Källqvist, T., hartnik, T., Thain, J.E., Evenset, A. (2004). Biological effects in sediment risk assessment and management. ICES Council Meeting documents.

Tollefsen, K.E., Ruus, A., Grung, M., Goksøyr, A., Dye, C., Hylland, K. (2002). Biomarker directed monitoring of toxic compounds in pelagic ecosystems. ICES Council Meeting Documents.

Øvrevik, J.; Tollefsen, K-E.; Nilssen, K. & Stenersen, J. (2000) Partial characterisation of sex-steroid binding proteins in plasma from Svalbard charr (Salvilinus alpinus L). In proceedings of the 6th International Symposium on Reproductive Physiology of Fish (ISRP’99) Bergen, July 1999. p.378

Tollefsen, K-E.; Frydenlund, J. & Stenersen, J. (2000) Estrogenic effects of di-n-butyl phthalate in Atlantic salmon (Salmo salar). In proceedings of the 6th International Symposium on Reproductive Physiology of Fish (ISRP’99) Bergen, July 1999. p.371

Tollefsen, K-E.; Kelley, A. & Stenersen, J. (1999) Detection of xenoestrogens in effluents from oil production activities. In proceedings of the 37th European congress of toxicology (Eurotox’99), Oslo, June 1999.Toxicological letter, suppl.1/99: 52.

Øvrevik, J.; Tollefsen, K-E.; Nilssen, K. & Stenersen, J. (1999) Potential use of Svalbard charr (Salvilinus alpinus L) for detection of xenoestrogens in artic regions. In proceedings of the 37th European congress of toxicology (Eurotox’99), Oslo, June 1999.Toxicological letter, suppl.1/99: 52.

Mathisen, FR., Tollefsen, K.E., Knudsen, F.R., Stenersen, J. (1998). Establishing an In Vitro Method for Detecting Estrogen-Mimicking Chemicals in Environmental Samples. Mar. Environ. Res. 46 (1), 176-176.

Knudsen, F.R.; Schou, A.F.; Wiborg, M.L.; Mona, E.; Tollefsen, K-E.; Mathisen, R. & Stenersen, J. (1997) Monitoring of Endocrine Substances in Effluents. In: Development of Ecotoxicity and Toxicity Testing of Chemicals. Proceeding of the 2nd Network Meeting. Nordic Council of Ministers TemaNord 1997: 524.

Wiborg, M.L., Kvistad, A.M., Mathisen, R., Tollefsen, K.E., Stenersen, J. (1997). Monitoring of Endocrine Substances in Effluents; Test Systems: Exposure of Fish, Liver Cell Culture, Steroid Receptor Assay. evelopment of Ecotoxicity and Toxicity Testing of Chemicals: Proceedings of the 2nd Network Meeting.

Ankley, G.; Bradbury, S.; Hermens, J.; Mekenyan, O. & Tollefsen K-E. (1997) Current Approaches to the use of Structure Activity Relationships (SARs) in identifying the hazards of Endocrine Modulating chemicals to Wildlife. In: Tattersfield, L. et al. SETAC-Europe/OECD/EC expert workshop on Endocrine Modulators and Wildlife: Assessment and Testing (EMWAT). Veldhoven, The Netherlands, 10-13 april 1997.

National reports (total: 18)

Skipperud, L., Alvarenga, E., Lind, O.C., Teien, H.C., Tollefsen, K.E., Salbu, B and Meen Wærsted, F. (2016). Effekter og miljørisiko knyttet til inngrep i områder med sulfidrike mineraler. Ås, Norway: NMBU.

Tollefsen, K.E., Bæk, K., Almeida, A.K., Haug, L.A., Norli, H.R., Odenmarck, S.R., Stenrød, M. (2016).

 Evaluation of the combined toxicity assessment and cumulative risk assessment of ecologically relevant mixtures of plant protection products (PPPs) under Norwegian conditions. NIVA report no. 7030-2016.

Petersen, K., Stenrød, M., Odenmarck, S.R., Fredriksen, L., Gomes, T., Backhaus, T., Tollefsen, K.E. (2015). Exposure and toxicity of mixtures of plant protection products (PPPs) in the environment under Norwegian conditions. Evaluation of a cumulative environmental risk assessment of PPPs. NIVA report 6830-2015

Petersen K, Stenrød M and Tollefsen KE (2014). Initial environmental risk assessment of combined effects of plant protection products in six different areas in Norway. NIVA report 6588-2013.

Lillicrap, A.D., Langford, K., Brooks, S., Tollefsen, K.E. (2009). Determination of the bioaccumulation and elimination of sucralose in the zebrafish, Danio rerio. NIVA report no. 5865-2009, ISBN 978-82-577-5600-0. Norwegian Institute for water Research (NIVA), Oslo, Norway, p. 21

Lillicrap, A.D., Langford, K., Brooks, S., Tollefsen, K.E., (2009). Determination of the bioaccumulation factor of sucralose in the freshwater alga, Pseudokirchneriella subcapitata. NIVA report no. 5864-2009, ISBN 978-82-577-5599-7. Norwegian Institute for water Research (NIVA), Oslo, Norway, p. 16

Lillicrap, A.D., Langford, K., Brooks, S., Tollefsen, K.E., (2009). Determination of the bioconcentration factor of sucralose in the crustacean Daphnia magna. NIVA-report no. 5866-2009, SBN 978-82-577-5601-7.Norwegian Institute for water Research (NIVA), Oslo, Norway, p. 17

Knudsen, S., Solberg, S., Watne, B.N., Høgåsen, T., Magnusson, J., Tollefsen, K.E., Arrestad, P.A., Reitan, O., Stebel, K., Walker, S.-E. (2006) Oppdatering av regional konsekvensutredning for petroleumsvirksomheten i Nordsjøen. Regulære utslipp til luft – konsekvenser. NILU report OR 80/2006, ISBN 82-425-1809-2. Norsk Institutt for Luftforskning (NILU), 2006. pp. 109.

Hylland, K., Grung, M., Ruus, A., Tollefsen, K. E., Børseth, J. F., Myhre, L. P., Bechmann, R. K., Jonsson, G. (2006). Biomarkers in monitoring - a review.  Norwegian Institute for Water Research, Oslo. Report SNO 5205-2006. 106 p.

Tollefsen, K. E., Bøyum, O., Kringstad, A., Finne, E. F., Odden, E., Grung, M. (2004). Water column monitoring of polar chemicals by use of POCIS passive samplers. Report SNO 4940-2005, NIVA, Oslo. pp.15.

Børseth, J.F., Tollefsen, K.E. (2004). Water column monitoring 2003 – final report. Report RF – 2004/039, Rogaland Research (RF), Stavanger.

Tollefsen, K. E. (2004). Vitellogenin induction in Atlantic cod, body burden of organic chemicals and benzo(a)pyrene hydroxylase in blue mussels - NIVA analysis report - Water column Survey 2003. Report no. 4822-2004, Norwegian Institute for Water Research (NIVA), Oslo.

Tollefsen, K.-E., Dye, C., Grung, M., Berntssen, M., Hartnik, T., Norrgren, L., Balaam, J., Thomas, K. V. (2003). Final report project 152452/720: Identification of ecologically relevant toxic components in effluents from offshore activities (OffTiE). Norwegian Institute for Water Research (NIVA)

Tollefsen, K.-E, Byberg, A.L., Kelley, A., Goksøyr, A. (2001) Toxicity identification and evaluation of produced water effluents. Project report to Norsk Hydro. Biosense Laboratories AS. p.7.

Tollefsen, K-E. (1998) Estrogenic effects of di-n-bytyl phthalate (DBP) on Atlantic salmon (Salmo salar). Special report for the Hazard evaluation of chemicals used in the construction of the railroad tunnel “Romeriksporten”. Dept. of Biology, University of Oslo.

Tollefsen, K-E. (1998) Endocrine disruptors in the aquatic environment. Annual report 1997. Dept. of Biology, University of Oslo.

Schive Fürst, C., Tollefsen, K-E. (1997) The determination of the Acute toxicity of Alkyl phenols through use of the Microtox®-test. Dept. of Biology, University of Oslo.

Tollefsen, K-E. (1997) Endocrine disruptors in the aquatic environment. Annual report 1996. Dept. of Biology, University of Oslo.

Tollefsen, K-E. (1997) Endocrine Disruptors in the Environment. Resymè of the IBC-conference. May 1997. Dept. of Biology, University of Oslo.