DigiSal. Towards the Digital Salmon: From a reactive to a pre-emptive research strategy in aquaculture
Systems biology will aid sustainability in salmon farming. Scarcity of fish oil has forced development of novel feedstuffs, challenging the salmon's metabolism as well as our understanding of it.
About the DigiSal project
Salmon farming in the future must navigate conflicting and shifting demands of sustainability, shifting feed prices, disease, and product quality. The industry needs to develop a flexible, integrated basis of knowledge for rapid response to new challenges. Project DigiSal will lay the foundations for a Digital Salmon: an ensemble of mathematical descriptions of salmon physiology, combining mathematics, high-dimensional data analysis, computer science and measurement technology with genomics and experimental biology into a concerted whole.
DigiSal will focus on challenges of novel feedstuffs, collaborating with the Foods of Norway centre for research-based innovation at NBMU. Salmon are carnivores but today aquaculture provides more than half their fat and protein from plants, challenging the metabolic system and affecting fish health and nutritional value of salmon meat. The newly sequenced salmon genome and related resources will enable a tightly integrated theoretical-experimental study of mechanistic interactions among genetic and feed factors.
Systems-oriented mathematical and statistical modelling will be central, using existing and novel knowledge e.g. on metabolic reaction networks to guide design of experiments through multiple iterations. Metabolic function of fish will be characterized via multiple omics technologies in feeding trials and in vitro tissue-slice culture. Gut microbiota will receive particular attention. The resulting massive data will be summarized via multivariate models to deliver a predictive understanding of a whole range of possible diets, much more efficiently than by traditional feeding trials alone. Data and models will be annotated using bio-relevant ontologies, so that new knowledge automatically connects to that which already exists. Future challenges will be met by quickly reanalysing existing information and understanding of salmon biology, identifying knowledge gaps, acquiring new data and incorporating it into a unified whole. Thus, we begin a shift from a reactive to a pre-emptive R&D strategy in aquaculture.
Project objective: Establish a systems biology framework for adapting salmon breeding and nutrition strategies to modern feedstuffs, blazing the trail for a Digital Salmon endeavour.
- Provide and validate a framework for a model-based account of genetic and environmental variation in salmon metabolism
- Unravelling the systemic role of gut microbiota in adapting to new feeds
- Provide and validate a theoretical framework for systematic identification of targets for steering EPA/DHA metabolism through concerted use of nutrition and genetics
- Provide the foundation for a Digital Salmon knowledge base enabling adaption of a transformative pre-emptive research and development strategy
DigiSal is part of the Digital Life project by the BIOTEK2021 biotechnology programme of the Research Council of Norway.
DigiSal in the news
- Storsatsing innen bioteknologi: Senter for digitalt liv Norge (DLN) (Tekna Biotek 2016-06-16, opptak fra arrangementet fins nede på siden. DigiSal starter 50 minutt uti sendingen.)
- The fishy biotech future (Norway Exports - Seafood, Fishing & Aquaculture 2016/2017: page 30-31)
- Nasjonalt senter for digitalt liv viser vei mot fremtiden (NBS-nytt 2015/4, tidsskrift for Norsk Biokjemisk Selskap)
- First tailbeats of the Digital Salmon (iScience blog 2015-10-22)
- NMBU-forsker: -Nå er vi på landslaget i bioteknologi (Østlandets Blad 2015-10-14, subscription required)
- NOK 250 million for a new biotechnology centre (Research Council of Norway 2015-10-07)
- Nyvinnende forskningsprosjekt vil bidra til mer bærekraftig oppdrettsnæring | Norges miljø- og biovitenskapelige universitet (NMBU 2015-10-02)
- NMBU tildelt millionprosjekt under nytt nasjonalt senter for bioteknologi (NMBU 2015-09-30)
- Kjempeløft for bioteknologi, skal hjelpe Norge på vei når oljen svikter (Aftenposten 2015-09-30)
Scientific coordinator. Leader of WP3: Omics and imaging. RNA sequencing expert.
Data and model manager.
Mathematical modeller. Biochemist.
Biochemist, metabolic modelling.
MSc student, biotechnology/metabolic modelling.
Modeller, systems geneticist.
Leader of WP1: Feeding trials. Heads the nutrition part of Foods of Norway, with which DigiSal interfaces closely.
Leader of WP4: Genomics. Salmon genome guru.
Molecular biologist, bioinformatician.
Head of the ELIXIR node at NMBU, focusing on the salmon genome.
Head of Foods of Norway.
AquaGen (salmon breeding company)
Dr. Jacob Torgersen, leader of WP2: In vitro studies. Molecular biologist.
Dr. Nina Santi, research director of AquaGen.
Norwegian University of Science and Technology
Prof. Per Bruheim, metabolomicist.
Dr. Zdenka Bartosova, metabolomicist.
Dr. Marit Hallvardsdotter Stafsnes, metabolomicist.
Dr. Per Winge, gene editor.
Prof. Trygve Brautaset, systems biologist.
Prof. Stig Omholt, visionary.
University of Bergen
Dr. Eivind Valen, bioinformatician.
Prof. Inge Jonassen, bioinformatician.
Institute for marine research
Dr. Anna Wargelius, functional genomicist.
Dr. Rolf Edvardsen, molecular biologist.
University of Tromsø
Prof. Nils Peder Willassen, head of the ELIXIR node at UiT, focusing on marine metagenomics.
University of Stirling
Prof. Michael Leaver, fish-nutritional geneticist.
Wageningen University and Research Centre
Systems and synthetic biology group:
Prof. Vítor Martins dos Santos.
Prof. Peter Schaap.
Dr. María Suárez-Diez.
Dr. Jasper Koehorst.
EWOS (feed producer)
Dr. Dominic Nanton, senior scientist.
FAIRDOM (consortium for findable, accessible, interoperable and reusable data, operations and models)
Dr. Natalie Stanford, director of community communications.
Dr. Stuart Owen, director of technical development.
13/10/2015 - 15:15