Umbrella 3C - Transgenerational and reproduction effects

  • Zebra


The focus of this area is reproduction, genotoxic effects and the underpinning explanatory mechanisms involving transcriptomic and epigenetic regulation. By following the offspring of exposed parents (mice and zebrafish), it is possible to test the hypothesis that radiation exposures during gametogenesis can cause developmental and radiation specific effects in offspring, and to link these to changes in gene expression and epigenetic landscape patterns. Previous results obtained for selenium deficient male mice exposed to gamma demonstrated reproduction failure when low antioxidant status is combined with stressors.

Published 10. December 2015 - 10:52 - Updated 28. September 2018 - 13:04