The aim of RA3 is to improve our understanding of biological responses to radiation. This is crucial for our ability to accurately assess risks and to plan for radiation protection. In particular, little is known about the impact of low radiation doses on humans and wildlife, whether on reproduction, embryo development, behaviour or cancer. Therefore, our key research questions have been:
- Why are some organisms and/or life-stages more sensitive to stressors than others?
- How does the presence of UV modify biological responses to other radiation?
- What mechanisms underpin the observed effects such as oxidative stress, genotoxicity, transcription and epigenetic regulation?
RA3 is divided into three interlinked umbrella projects:
- Umb3A - Mechanisms determining species radiosensitivity
- Umb3B - Combined toxicity and cumulative risk assessment
- Umb3C - Transgenerational hereditary, reproductive and epigenetic effects
Key publications
Hurem, S., Rasmussen E.M.K., Brede D.A., Lindeman, L., Lyche, J.L., Alestrøm, P., Christensen, T., Effects of combined exposure effects of low dose UVB and gamma radiation during early life in the zebrafish (Danio rerio). Photochemical & Photobiological Sciences (to be submitted)
Martin, L.M., Kamstra, J.H., Hurem, S., Lindeman L., Brede, D.A., Aanes, H., Babiak, I., Arenal., A., Oughton, D.H., Salbu, B., , Lyche, J.L., Alestrom, P. Altered non-coding RNA expression profile in F1 progeny one year after parental irradiation is linked to adverse effects in zebrafish. Scientific reports (submitted)
Lindeman, L.C., Kamstra, J.H, Ballangby, J., Hurem, S., Martin, L., Brede, D.A., Teien, H.C., Oughton, D.H., Salbu, B., Lyche, J.L., Aleström, P., 2019. Gamma radiation induces locus specific changes to histone modification enrichment in zebrafish and Atlantic salmon. PLoS One 14(2), e0212123.
Kamstra, J.H., Hurem, S., Martin L. M., Lindeman, L., Legler, J., Oughton, D.H., Salbu, B., Brede, D.A., Lyche, J.L., Aleström, P., 2018. Ionizing radiation induces transgenerational effects of DNA methylation in zebrafish. Scientific Reports 8(1), 15373.
Hurem, S., Fraser, T., Gomes, T., Mayer, I., Christensen, T., 2018. Sub-lethal UV radiation during early life stages alters the behaviour, heart rate and oxidative stress parameters in zebrafish (Danio rerio). Ecotoxicology and Environmental Safety 166, 359-365.
Hurem, S., Martin, L.M., Lindeman, L., Brede, D.A., Salbu, B., Lyche, J.L., Aleström, P., Kamstra, J., 2018. Parental exposure to gamma radiation causes progressively altered transcriptomes linked to adverse effects in zebrafish offspring. Environmental Pollution 234, 855-863.
Hurem, S., Gomes, T., Brede D.A., Mayer, I., Lobert, V.H., Mutoloki, S., Gutzkow, K.B., Teien, H.C., Oughton D., Aleström, P., Lyche, J.L., 2018. Gamma irradiation during gametogenesis in young adult zebrafish causes persistent genotoxicity and adverse reproductive effects. Ecotoxicology and Environmental Safety 154, 19-26.
Hurem, S., Gomes, T., Brede, D.A., Lindbo-Hansen, E., Mutoloki, S., Fernandez, C., Mothersill, C., Salbu, B., Kassaye, Y.A., Olsen, A.K., Oughton, D.H., Aleström, P., Lyche, J.L., 2017. Parental gamma irradiation induces reprotoxic effects accompanied by genomic instability in zebrafish (Danio rerio) embryos. Environmental Research 159, 564-578.
Hurem, S., Martin, L.M., Brede, D.A., Skjerve, E., Nourizadeh-Lillabadi, R., Lind, O.C., Christensen, T., Berg, V., Teien, H.-C., Salbu, B., Oughton, D.H., Alestrom, P., Lyche, J.L., 2017. Dose-dependent effects of gamma radiation on the early zebrafish development and gene expression. PLoS One 12, e0179259.
