The CERAD CoE has been designed to answer the following overarching hypotheses:
- Radioactive particle releases: Air/water transport of particles will differ from that of aerosols/ions.
- Ecosystem transfer, biological uptake and the subsequent accumulation in living organisms of radionuclides are driven by changes in radionuclide speciation over time.
- Kinetics: Improved transfer and exposure assessments to take account of time- and temperature dependent changes will reduce uncertainty.
- Responses at the cellular or molecular biomarker level can be correlated with effects at the organism level. Particle exposure and localised doses can increase risks.
- Multiple stressors: Ionising radiation, UV and other chemical stressors act by either same modes of action or different modes of action or at different sites. Combined responses will deviate from simple dose or concentration assessments and might give additive, synergistic or antagonistic effects.