We study different molecular mechanisms to understand antibiotic resistance and identify novel antimicrobial target sites in pneumococci (S. pneumoniae) and staphylococci (S. aureus). These pathogens are responsible for millions of deaths worldwide every year.

It is increasingly difficult to treat infections due to the emergence and spread of antibiotic resistant bacteria (including penicillin-resistant S. pneumoniae and methicillin-resistant S. aureus, MRSA). An understanding of the underlying mechanisms behind antibiotic resistance will lead to better treatment methods.