• AFM
    Darya Dubava

Single cell lipidomics of oleaginous microorganisms by modern vibrational spectroscopy

The project is related to studying fundamental aspects of lipid accumulation in oleaginous microorganisms by modern vibrational spectroscopy.


Norwegian Research Council - IS-AUR

Project number: 281357
Period covered - start date: 01.01.16
Period covered - end date: 31.12.2019
Project's coordinator: Volha Shapaval  

Project partner
Paris-Sud University - Institut de Chimie Physique


Oleaginous microorganisms are considered as one of the main alternative sources of lipids for human, animal and industrial use. Currently, a lot of activities are going on the developing sustainable production processes for microbial lipid production by using different types of oleaginous microorganisms and low-cost substrates (food and agricultural rest materials, industrial wastes). But, in order to develop a sustainable microbial lipid production process, a deeper understanding of the fundamental aspects of lipid accumulation in microbial cells is urgently needed.

Modern vibrational spectroscopy is an emerging technology for single cell lipidomics, which allows to study lipid accumulation processes at the single cell level. FunLip project will initiate and establish a long-term collaboration related to spectroscopy-based single cell lipidomics between the BioSpec group at NMBU and the Paris-Sud University group (represented by Alexandre Dazzi and Ariane Deniset-Besseau). The Paris-Sud University group is the main developer of one of the modern vibrational spectroscopy techniques (nanoFTIR spectroscopy) which have enormous potential in single cell lipidomics studies.

AFM-IR nanospectroscopy image of a cross-sectioned hyphae of oleaginous Mucor circinelloides fungi containing lipid bodies (Measured at Paris-Sud University, Paris, France).
Darya Dubava

Published 22. August 2018 - 16:08 - Updated 30. March 2020 - 10:05