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Comparisons of infant escherichia coli isolates link genomic profiles with adaptation to the ecological niche

Comparisons of infant Escherichia coli isolates link genomic profiles with adaptation to the ecological niche

In collaboration with CEES at uio we have been able to link genetic information to ecological properties for E. coli isolated from children.

Comparisons of infant escherichia coli isolates link genomic profiles with adaptation to the ecological niche

Despite being one of the most intensely studied model organisms, many questions still remain about the evolutionary biology and ecology of Escherichia coli. An important step toward achieving a more complete understanding of E.coli biology entails elucidating relationships between gene content and adaptation to the ecological niche.Here, we present genome comparisons of 16 E.coli strains that represent commensals and pathogens isolated from infants during a specific time period in Trondheim, Norway. Using differential gene content, we characterized enrichment profiles of the collection of strains relating to phylogeny, early vs. late colonization, pathogenicity and growth rate. We found clear gene content distinctions relating to the various grouping criteria. We also found that different categories of strains use different genetic elements for similar biological processes. Our results indicate a general pattern where alternative genetic pathways lead toward a consistent ecological role for E.coli as a species. Within this framework however, we saw selection shaping the coding repertoire of E.coli strains toward distinct ecotypes with different phenotypic properties.

You can read the whole article here:

BMC Genomics. 2013 Feb 5;14(1):81. [Epub ahead of print] Comparisons of infant Escherichia coli isolates link genomic profiles with adaptation to the ecological niche.de Muinck EJ, Lagesen K, Afset JE, Didelot X, Rønningen KS, Rudi K, Stenseth NC, Trosvik P.

Published 27. June 2014 - 9:30 - Updated 23. May 2017 - 19:35

Norwegian University of Life Sciences (NMBU)

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