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Early infant growth rate linked to composition of gut microbiota commented in science daily

Early Infant Growth Rate Linked to Composition of Gut Microbiota - commented in Science Daily

The composition of gut microbiota in a newborn baby's gut has been linked to the rate of early infant growth, reports research published this week in PLOS Computational Biology.

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Early infant growth rate linked to composition of gut microbiota commented in science daily

Some obesity trajectories are set early in life, with rapid weight gain being a risk factor for later development of obesity. Recently, much attention has been given to findings indicating that gut microbiota may play a role in obesity development. The existence of time-dependent exposure windows, which rely on stimuli from the gut to initiate healthy development, gives the evolution of early life gut microbiota a critical role in human health. We identified children that followed their expected growth trajectories at six months of life, and those that had deviated. We then developed a novel statistical approach that allowed the identification of longitudinal gut microbiota patterns (e.g. a particular species was detected at days 4, 10, and 30 and not detected at day 120) that were associated with expected growth, while appropriately restricting the false discovery rate. We further identified when a deviation from the proposed longitudinal gut microbiota patterns would result in an abnormal growth outcome (either rapid or decreased growth at six months of life). We found developmental pathways of Staphylococcus species and Escherichia coli that were associated with expected growth, as well as indications that Bacteroides species at day 30 was associated with growth

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Article Source:Novel Developmental Analyses Identify Longitudinal Patterns of Early Gut Microbiota that Affect Infant Growth

White RA, Bjørnholt JV, Baird DD, Midtvedt T, Harris JR, et al. (2013)Novel Developmental Analyses Identify Longitudinal Patterns of Early Gut Microbiota that Affect Infant Growth.PLoS Comput Biol 9(5):e1003042.doi:10.1371/journal.pcbi.1003042

Published 27. June 2014 - 9:30 - Updated 23. May 2017 - 19:34