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Diversity of intestinal microbiota in infancy and the risk of allergic disease in childhood

Diversity of intestinal microbiota in infancy and the risk of allergic disease in childhood

We review the possibility that bacterial diversity is important for allergic diseases. This was done in close collaboration with Pact study at NTNU.

Diversity of intestinal microbiota in infancy and the risk of allergic disease in childhood

Numerous studies have attempted to describe specific microbiota deviations that may precede atopic sensitization and atopic disease in childhood. This has given rise to a hypothesis suggesting that a reduced intestinal microbial diversity in infancy increases the risk of allergic manifestations. This review intends to sum up the main findings and discuss relevant exposures that regulate intestinal microbial diversity. RECENT FINDINGS: Taken together the three studies in this review lend support to the diversity hypothesis, but reported differences related to atopic sensitization and clinical expression are discussed. A summary on analytic methods and functional aspect of the microbiota in allergic disease is presented to ameliorate a presentation of recent articles on environmental and host-factors regulating microbiota composition and diversity

For more information:

Storro, O., Avershina, E. and Rudi, K., 2013. Diversity of intestinal microbiota in infancy and the risk of allergic disease in childhood. Curr Opin Allergy Clin Immunol.

Published 27. June 2014 - 9:30 - Updated 23. May 2017 - 19:34