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Arbeidsområder
- Virologi
- Oppdrettslaks
- PRV
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Publikasjoner
- Vendramin N, Alencar ALF, Iburg TM, Dahle MK, Wessel O, Olsen AB, et al. Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV). Vet Res. 2018;49(1):30. Epub 2018/03/15. doi: 10.1186/s13567-018-0524-z. PubMed PMID: 29534748.
- Dhamotharan K, Vendramin N, Markussen T, Wessel O, Cuenca A, Nyman IB, et al. Molecular and Antigenic Characterization of Piscine orthoreovirus (PRV) from Rainbow Trout (Oncorhynchus mykiss). Viruses. 2018;10(4). Epub 2018/04/05. doi: 10.3390/v10040170. PubMed PMID: 29614838.
- Teige LH, Lund M, Haatveit HM, Rosaeg MV, Wessel O, Dahle MK, et al. A bead based multiplex immunoassay detects Piscine orthoreovirus specific antibodies in Atlantic salmon (Salmo salar). Fish Shellfish Immunol. 2017;63:491-9. doi: http://doi.org/10.1016/j.fsi.2017.02.043.
- Haatveit HM, Wessel O, Markussen T, Lund M, Thiede B, Nyman IB, et al. Viral protein kinetics of piscine orthoreovirus infection in Atlantic salmon blood cells. Viruses. 2017;9(3). doi: http://doi.org/10.3390/v9030049.
- Di Cicco E, Ferguson HW, Schulze AD, Kaukinen KH, Li S, Vanderstichel R, et al. Heart and skeletal muscle inflammation (HSMI) disease diagnosed on a British Columbia salmon farm through a longitudinal farm study. PLoS One. 2017;12(2):e0171471. doi: http://doi.org/10.1371/journal.pone.0171471.
- Hauge H, Vendramin N, Taksdal T, Olsen AB, Wessel O, Mikkelsen SS, et al. Infection experiments with novel Piscine orthoreovirus from rainbow trout (Oncorhynchus mykiss) in salmonids. PLoS One. 2017;12(7):e0180293. Epub 2017/07/06. doi: 10.1371/journal.pone.0180293. PubMed PMID: 28678799; PubMed Central PMCID: PMCPMC5497981.
- Wessel Ø, Braaen S, Alarcon M, Haatveit H, Roos N, Markussen T, et al. Infection with purified Piscine orthoreovirus demonstrates a causal relationship with heart and skeletal muscle inflammation in Atlantic salmon. PLoS One. 2017;12(8):e0183781. Epub 2017/08/26. doi: http://dx.doi.org/10.1371/journal.pone.0183781. PubMed PMID: 28841684.
- Johansen LH, Dahle MK, Wessel O, Timmerhaus G, Lovoll M, Rosaeg M, et al. Differences in gene expression in Atlantic salmon parr and smolt after challenge with Piscine orthoreovirus (PRV). Mol Immunol. 2016;73:138-50. doi: http://doi.org/10.1016/j.molimm.2016.04.007.
- Haatveit HM, Nyman IB, Markussen T, Wessel O, Dahle MK, Rimstad E. The non-structural protein muNS of piscine orthoreovirus (PRV) forms viral factory-like structures. Vet Res. 2016;47(1):5. doi: http://doi.org/10.1186/s13567-015-0302-0.
- Bjorgen H, Wessel O, Fjelldal PG, Hansen T, Sveier H, Saebo HR, et al. Piscine orthoreovirus (PRV) in red and melanised foci in white muscle of Atlantic salmon (Salmo salar). Vet Res. 2015;46:89. Epub 2015/09/09.
- Wessel Ø, Olsen CM, Rimstad E, Dahle MK. Piscine orthoreovirus (PRV) replicates in Atlantic salmon (Salmo salar L.) erythrocytes ex vivo. Vet Res. 2015;46(26). doi: http://dx.doi.org/10.1186/s13567-015-0154-7.
- Wessel Ø, Nyman IB, Markussen T, Dahle MK, Rimstad E. Piscine orthoreovirus (PRV) ơ3 protein binds dsRNA. Virus Res. 2015;198(0):22-9. doi: http://dx.doi.org/10.1016/j.virusres.2015.01.001.
- Dahle MK, Wessel O, Timmerhaus G, Nyman IB, Jorgensen SM, Rimstad E, et al. Transcriptome analyses of Atlantic salmon (Salmo salar L.) erythrocytes infected with piscine orthoreovirus (PRV). Fish Shellfish Immunol. 2015;45(2):780-90. doi: http://dx.doi.org/10.1016/j.fsi.2015.05.049.
- Finstad OW. Pathogenesis of Piscine orthoreovirus (PRV) infection in Atlantic salmon (Salmo salar) [PhD]. Oslo: Norwegian University of Life Sciences; 2014.
- Finstad OW, Dahle MK, Lindholm TH, Nyman IB, Lovoll M, Wallace C, et al. Piscine orthoreovirus (PRV) infects Atlantic salmon erythrocytes. Vet Res. 2014;45(1):35. doi: http://dx.doi.org/10.1186/1297-9716-45-35.
- Markussen T, Dahle MK, Tengs T, Løvoll M, Finstad ØW, Wiik-Nielsen CR, et al. Sequence analysis of the genome of piscine orthoreovirus (PRV) associated with heart and skeletal muscle inflammation (HSMI) in Atlantic salmon (Salmo salar). PLoS One. 2013;8(7):e70075. doi: http://dx.doi.org/10.1371/journal.pone.0070075.
- Finstad ØW, Falk K, Løvoll M, Evensen Ø, Rimstad E. Immunohistochemical detection of piscine reovirus (PRV) in hearts of Atlantic salmon coincide with the course of heart and skeletal muscle inflammation (HSMI). Vet Res. 2012;43(1):27. doi: http://dx.doi.org/10.1186/1297-9716-43-27.
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Forskning & prosjekt
Prosjekter
PRV er vidt utbredt i oppdrettslaks og er årsaken til HSMB. Hovedmålet med prosjektet er å kartlegge PRVs motstandsdyktighet overfor desinfeksjon, og undersøke om det er virulensforskjeller mellom ulike PRV-stammer.
Viral diseases represent a huge problem for the global aquaculture industry, and many viral diseases cannot be effectively controlled using the current generation of vaccines.
De siste to tiår har norsk lakseoppdrett opplevd et økende antall utbrudd av sykdommen hjerte- og skjelettmuskel- betennelse (HSMB) som er forårsaket av det meget utbredte piscine orthoreovirus (PRV).
Successful vaccination is an efficient way to increase fish health and welfare. Controlling the infections among farmed salmon also reduce the risk for spread of infectious agents and diseases to the environment.
In the Viva Fish (Fish Virus Vaccines) platform project, we aim to generate knowledge, tools and methods that will contribute to better vaccines against viral diseases in farmed fish. The viral diseases we focus on are Pancreas disease (PD), Heart and skeletal muscle inflammation (HSMI), Cardiomyopathy (CMS) and Infectious salmon anemia (ISA).
Forskningsområder
Tema:
- Veterinærmedisin
- Akvakultur
Forskningsområder:
- Veterinærmedisin