Course code KJM314

KJM314 Applied Organic Analytical Chemistry

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Norsk emneinformasjon

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Showing course contents for the educational year starting in 2020 .

Course responsible: Roland Peter Kallenborn
Teachers: Ivo Havranek, Aasim Musa Mohamed Ali, Hanne Marie Devle, Dag Ekeberg, Siri Merete Grønhovd, Yngve Henning Stenstrøm, Morten Sørlie
ECTS credits: 10
Faculty: Faculty of Chemistry, Biotechnology and Food Science
Teaching language: EN, NO
(NO=norsk, EN=Engelsk)
Limits of class size:
20
Teaching exam periods:
This course starts in the autumn parallel. This course has teaching/evaluation in the autumn parallel.
Course frequency: Annual
First time: 2012V
Course contents:

The course will focus on various applications for organic analytical chemistry:

  • HPLC: for purification and isolation of organic compounds
  • GC/MS and GC/ECD: within environmental chemistry and pollution
  • LC/MS, GC/MS and GC/FID: for product control in technical applications and synthesis
  • LC/MS and GC/MS: for purification and product control within drug and food production.

Quantitative standard methods like GC/MS, as well as purification methods like column chromatography and SPE, Silica based, and Alumina-based chromatography will be applied and evaluated. Critical method validation and quality control will be integrated into both lectures and practice.

The teach goals of the course reflect UN Sustainable development goals 1, 3, 4, 6, 7, 9, 11, 12, 13, 14 & 15

Learning outcome:

GENERAL: Practical guidance is provided into the analytical organic chemistry as a versatile tool in a variety of applications spanning from technical control, product control to pharmaceutical application, food safety, environmental chemistry, organic pollutant quantification and medical/ health-related applications.   

EXPECTED OUTCOME: After completion, the candidates should have knowledge of, and be familiar with, the various analytical techniques used for sample purification, method validation  and quantitative analysis using a variety of chromatographic separation and detection techniques, including mass spectrometry, UV-VIS detection etc. Interpretation of chromatograms, quality check and quantification procedures are central topics.

EXPECTATIONS: Students will become familiar with the validation of methods for specific applications and will be able to select appropriate methods for a specific application within the field of organic analytical chemistry. Good knowledge of chromatographic principles, hyphenation to different detectors is a prerequisite for the course. Furthermore, the capacity for independent and self-initiated learning and active practical contribution to the lgroup work in the laboratry is expected.

Learning activities:
There will be lectures and seminars where students are expected to be involved in a constructive and active way. The regular seminars will be arranged as "flipped classroom" where the students will be given topics related to method development, validation and quality assurance (QA). Based on their preparations, the student groups will discuss their findings in plenum. Students are given a project to work on and present in plenary. Based upon the chosen laboratory experiments (groups of 2-3 students; 8-10 laboratory days are planned) group laboratory reports will be prepared for grading. The respective groups will prepare a final presentation of their findings. The combined written report and the oral presentations will be graded (counts 60 % of the final grade).
Teaching support:
Office hours will be announced for individual discussions and problem solving.Seminars will be held in which the laboratory work is discussed.  All groups will have access to dedicated literature, reports and practical information for planning and data interpretation.The dedicated CANVAS link (KJM314) will be actively utilised for discussions and information source.
Syllabus:
Lecture printouts as well as selected scientific publications.
Prerequisites:
The course is based on scientific knowledge in generell Chromatography (KJM310) and Mass Spectrometry (KJM313) (both may be taken in parallel).
Recommended prerequisites:
A good understanding of the general principles and methods in organic analytical chemistry is a prerequisite for the successful completion of the course. In addition, basic knowledge in general statistics, quality control in quantitative analytical methods as well as method validation in organic analytical chemistry will be helpful.
Mandatory activity:
Participation in seminarsParticipation in lecturesParticipation in laboratory experimentsParticipation in oral project presentations
Assessment:
  • 1 hours oral exam, counts 40 %
  • Written report and oral project presentation, counts 60 %
Nominal workload:
  • Lectures: 52 hours.
  • Practical exercises: 78 hours.
  • Individual study: 170 hours (including project work).
Entrance requirements:
Graduate chemistry competence  - Special requirements in Natural Science
Type of course:
4 hours with lectures/ seminars and 6 hours with laboratory exercises per week.
Examiner:

An external examiner evaluates the project reports  and the oral examinations.

The oral project evaluations will be evaluated by the course responsible and integrated thereafter into the Report & presentation grading.

Examination details: Continuous exam: A - E / F