Course code KJB310

KJB310 Protein Chemistry

Norsk emneinformasjon

Search for other courses here

Showing course contents for the educational year 2019 - 2020 .

Course responsible: Gustav Vaaje-Kolstad
Teachers: Vincentius Gerardus Henricus Eijsink
ECTS credits: 10
Faculty: Faculty of Chemistry, Biotechnology and Food Science
Teaching language: EN, NO
(NO=norsk, EN=Engelsk)
Limits of class size:
Teaching exam periods:
This course starts in Autumn parallel. This course has teaching/evaluation in Autumn parallel.
Course frequency: Annually
First time: Study year 2004-2005
Course contents:

The lectures start 4-6 weeks before the exercises, in order to give the necessary theoretical background. The exercises are one full day per week with a teacher present. It is strongly advised to participate in an active way in the computer exercise since this is of paramount importance for understanding the topics.

Basic knowledge in bioinformatics and use of computers is an advantage. Those who do not have these skills are recommended to go through an introductory course in bioinformatics that can be found in Canvas. 

It should be emphasized that this course is intended for master's degree students and requires the ability to work independently in the field using computers and the internet.

The course also contains a practical computerlab course that teaches the students how to analyze protein sequences and structures using protein bioinformatic techniques commonly used. There will be focus on learning the 'PyMol' software, which is used to analyze and visualize 3D protein structures. The students will learn how to identify functional regions of the proteins structures as well as how to visualize their findings via informative (and advanced) graphics and animations.

The students will gain experience in how to prepare and deliver effective oral and written presentations of technical information and scientific results. They will learn to think critically and solve complex problems, as well as learn to accurately interpret current research literature.

Learning outcome:

After completion of KJB310 protein chemistry, the candidate will have the following learning outcomes:


A student who has completed and passed KJB310

  • Has deep knowledge of protein building blocks and structure.
  • Understands the importance of protein structure for stability and biological activity, and how a protein structure can be determined.
  • Understands the background and use of the most common bioinformatic methods used to study the structure and function of proteins.
  • Has deep knowledge of different types of proteins and their biological functions.
  • Has good understanding of how proteins have developed their properties through evolution and how new functions emerge.
  • Understands how proteins achieve their three dimensional structure (protein folding) and what role proteins play in various diseases.
  • Understands the interaction between proteins (protein-protein interactions), how this can be investigated and how this affects protein function.
  • Understands how enzymes catalyze reactions, how such reactions can be measured and how the results can be analyzed (enzymology).
  • Understands and can explain how to improve / modify the properties of proteins using methods such as protein engineering and directed evolution.
  • Has a good overview and understanding of the experimental methods that are used to analyze both protein function and structure.


A student who has completed and passed KJB310

  • Can find functional information about a protein sequence using bioinformatics methods.
  • Can derive functional information for a protein by analyzing its three-dimensional structure.
  • Can make good and informative figures of protein structures and sequence alignments
  • Can write an illustrated academic text OR create a digital story about a given topic within protein chemistry.
  • Can read, understand and critically evaluate academic articles within the field.

General competence

When one has completed and passed the KJB310 Protein Chemistry

  • One has gained in-depth understanding of how proteins work and can reflect on, among other things 1) how proteins affect all forms of life 2) how protein function has evolved 3) how to develop and use proteins for industrial use 4) which roles proteins play in disease.
  • One can judge and critical interpret published scientific papers within the field.
  • One is aware of the dangers and pitfalls of protein sequence analysis using bioinformatics.
  • One can contribute constructively and creatively in academic discussions and meetings within the field of protein chemistry.
Learning activities:
Lectures, some with group exercises.Weekly exercises with a teacher present, in which students work in pairs on a computer, using databases and analysis tools available on the Internet and on the local computer.Compulsory semester exercise; a variety of exercise types can be chosen from.
Teaching support:
Questioning hours will be organized right before the exam.Two teachers will be available for questions during the weekly exercises.Lecture notes will be available in Canvas.Collaboration with the Science Park for the use of haptic learning aids (3D visualization combined with force feedback equipment)
Arthur M. Lesk: Introduction to Protein Science, Oxford University Press, Third Edition, 2016LecturesCourse bookletSemester exercise
Biochemistry equivalent to KJB200.
Recommended prerequisites:
Bioinformatics equivalent to BIN210.  Biochemistry laboratory course, equivalent to KJB201. 
Mandatory activity:
Approved semester assignment.
Written examination, 3.5 hours, counts 100 %.
Nominal workload:
Lectures: 35 hours. Exercises: 60 hours. Individual study: 205 hours.
Entrance requirements:
Special requirements in Science
Reduction of credits:
There is some overlap with BIN210, this does not reduce the number of credits earned, however.
Type of course:

Per normal week:

4 hours lectures 8 hours exercise.

An external examiner approves the examination questions and marks a minimum of 25 selected examination papers.
Allowed examination aids: A1 No calculator, no other aids
Examination details: One written exam: A - E / F