BIO210 Molecular Biology
There may be changes to the course due to to corona restrictions. See Canvas and StudentWeb for info.
Showing course contents for the educational year 2021 - 2022 .
Course responsible: Bao Dung Diep
Teachers: Thomas Førland Oftedal, Sofie Sagvaag Kristensen, Gro Anita Hvidsten Stamsås
ECTS credits: 10
Faculty: Faculty of Chemistry, Biotechnology and Food Science
Teaching language: NO
Limits of class size:
Teaching exam periods:
This course starts in Autumn parallel. This course has teaching/evaluation in Autumn parallel.
Course frequency: Annually.
First time: 2004V
- DNA's structure and organisation in the cell.
- DNA replication, recombination and repair.
- Transcription and protein synthesis.
- Transposons and bacteriophages.
- Structures of operons, promoters, activators, repressors.
- RNA splicing.
- DNA binding motives in proteins.
- Functional, small RNA molecules.
- The lactose operon
- Regulation of the tryptophan operon
- The lambda bacteriophage
- Catabolic repression
Students will have a detailed knowledge of all the important steps and proteins/enzymes involved in central biosyntheses, the interplay between the enzymes, the connections between the different biosyntheses. Students will also be able to understand how genes are expressed and regulated, and how cells/bacteria respond to changes in the environments, e.g., during energy limitations or DNA damages.
Acquired skills can later contribute in the development of various molecular tools to solve important problems in the society or in the environment. E.g., to
- improve health by producing vitamines and better and healthier food,
- secure life quality on land and in waters by removing toxic pollutants through enzymatic processes,
- produce more food using genetic technologies, and
- develop new medicines for human and veterinary use.
These opportunities and challenges are central in many UN sustainable development goals.
The students shall after the course (i) have increased understanding on how central biosyntheses take place at a molecular level in cells, and (ii) can communicate and participate in discussions on topics related to biosynthesis, the buildup of macromolecules, gene regulation, DNA repair.
Lectures and colloquia.
The teacher has designated office hours for consultation.
A series of 10 double-hour colloquia during the semester
Molecular Biology of the Gene 7th Edition by https://www.amazon.com/James-D-Watson/e/B001KD83S2/ref=dp_byline_cont_ebooks_1James D. Watson (Author), https://www.amazon.com/s/ref=dp_byline_sr_ebooks_2?ie=UTF8&field-author=Tania A. Baker&text=Tania A. Baker&sort=relevancerank&search-alias=digital-textTania A. Baker (Author), https://www.amazon.com/Stephen-P-Bell/e/B00CTTBTKK/ref=dp_byline_cont_ebooks_3Stephen P. Bell (Author), https://www.amazon.com/Alexander-Gann/e/B00CTUIFJM/ref=dp_byline_cont_ebooks_4Alexander Gann (Author), https://www.amazon.com/s/ref=dp_byline_sr_ebooks_5?ie=UTF8&field-author=Michael Levine&text=Michael Levine&sort=relevancerank&search-alias=digital-textMichael Levine (Author), https://www.amazon.com/s/ref=dp_byline_sr_ebooks_6?ie=UTF8&field-author=Richard Losick&text=Richard Losick&sort=relevancerank&search-alias=digital-textRichard Losick (Author)
Chapter 2: Genetic information.
Chapter 4: DNA.
Chapter 5: RNA.
Chapter 8: Genome structure, chromatin and the nucleosome.
Chapter 9: DNA replication.
DNA damages and repair mechanisms, mutations
Chapter 10: Mutability and repair of DNA.
Chapter 11: Homologous recombination.
Chapter 12: Site-specific recombination and transposition.
Chapter 13; Transcription.
Chapter 14: RNA splicing.
Chapter 15: Translation.
Chapter 16: Genetic code.
Chapter 18: Gene regulation in prokaryotes.
Chapter 19: Transcriptional regulation in eukaryotes.
Chapter 20: Regulatory RNAs.
Chapter 7: Techniques of Molecular Biology.
- Cell Biology equivalent to BIO100.
- Microbiology equivalent to BIO130.
The lectures and colloquia are not compulsory but students are highly recommended to participate.
Twice with 45 min midterm test (multiple choice). The first counts 10 % and the second counts 15 % of the final grade.
3.5 hour written final exam, counts 75 %. (*)
*: Final exam consists of three individual tasks. The result from the final exam counts only when at least 2 of 3 tasks are at passing grade (40% correct).
- Lectures: 46-48 hours.
- Mid Term Test: 45 minutes
- Colloquia: 20-24 hours.
- Individual study: 137 hours.
Special requirements in Science.
Type of course:
First three weeks: 3 x 2h-lectures per week.
After that: 2 x 2h-lectures and 1 x 2h-colloquium per week.
Students must pass the exam in this course (or equivalent) to get admission to the course "BIO211 Laboratory course in molecular biology".
Midterm tests: An external examiner approves the examination tasks, but is not involved in grading the test papers.
Final exam: An external examiner approves the examination tasks and grades a minimum of 25 selected exam papers.
Allowed examination aids: A1 No calculator, no other aids
Examination details: Portfolio assessment: A - E / F