Course code BIO210

BIO210 Molecular Biology

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Showing course contents for the educational year starting in 2019 .

Course responsible: Bao Dung Diep
Teachers: Thomas Førland Oftedal, Sofie Sagvaag Kristensen
ECTS credits: 10
Faculty: Faculty of Chemistry, Biotechnology and Food Science
Teaching language: NO
(NO=norsk, EN=Engelsk)
Limits of class size:
200
Teaching exam periods:
This course starts in Autumn parallel. This course has teaching/evaluation in Autumn parallel.
Course frequency: Annually.
First time: 2004V
Course contents:
  • DNA's structure and organisation in the cell.
  • DNA replication, recombination and reparation.
  • Transcription and protein synthesis.
  • Transposons and bacteriophages.
  • Structures of operones, promoters, activators, repressors.
  • Intron-exon-splicing.
  • DNA binding motives in proteins.
  • Functional, small RNA molecules.
Learning outcome:

Knowledge: The course will give students a theoretical knowledge on DNA synthesis (replication, recombination and reparation), RNA synthesis, protein synthesis and gene regulation, at a molecular level. Students will get a basic understanding on the interactions between DNA and proteins in connection with DNA and RNA synthesis, DNA packaging and gene regulation. Both bacterial and eukaryotic systems will be used, but with special focus on the former. We will focus on following model systems for gene regulation:

  • The lactose operon
  • Regulation of the tryptophan operon
  • The lambda bacteriophage
  • Catabolic repression

Skills

Students will have a detailed knowledge on all the important steps and proteins/enzymes involved in Central biosynteses, the interplay between the enzymes, the connections between the different biosyntheses. Students will also be able to understand how genes are expressed and regulated, and how cells/bacteria respond to changes in the enviroments, e.g., during energy limitations or DNA damages.

General competence

The students shall after the course (i) have increased understanding on how Central biosyntheses take place at  a molecular level in cells, and (ii) can communicate and participate in discussions on topics related to biosynthesis, the buildup of makromolecules, gene regulation, DNA repair.

Learning activities:
Lectures. Colloquia.
Teaching support:

The teacher has designated office hours for consultation.

dzung.diep@nmbu.no

Canvas.

Syllabus:
Given in the first lecture.
Prerequisites:
Biochemistry equivalent to KJB200.Genetics equivalent to BIO120.
Recommended prerequisites:
  • Cell Biology equivalent to BIO100.
  • Microbiology equivalent to BIO130.
Mandatory activity:
The lectures are not compulsory but students are highly recommended to participate.
Assessment:
3.5 hour written exam, counts 100 %.
Nominal workload:
  • Lectures: 46 hours.
  • Seminars and preparations: 24 hours.
  • Individual study: 230 hours.
Entrance requirements:
Special requirements in Science.
Type of course:
2x2 hrs lecture per week.  2 hrs colloquium per week. 
Note:
Students must pass the exam in this course (or equivalent) to get admission to course "BIO211 Laboratory course in molecular biology".
Examiner:
An external examiner approves the examination tasks and grades a minimum of 25 selected exam papers.
Examination details: Continuous exam: A - E / F