Leptospira interrogans strain RGA

LEPRESNOR - Role of zoonotic Leptospira spp. in Norway from a One Health perspective and their host-pathogen interactions

Leptospirosis is a zoonosis caused by bacteria called Leptospira. We want to clarify the role of possible maintenance hosts for the disease in Norway and understand the pathogens' virulence mechanisms better.

Leptospira interrogans strain RGA
02. Feb. 2022 - 31. des. 2015
Norwegian University of Life Sciences

Leptospirosis is considered the most widespread zoonotic disease in the world with a notable (re-)emergence during the past decade. The World Health Organization (WHO) recognizes leptospirosis outbreaks to be driven by climate and environment since warmer and wetter conditions favor the spread of the infection. Leptospira have a broad host range and leptospirosis may present with a broad spectrum of clinical symptoms. While maintenance hosts like rats generally remain asymptomatic, in humans, who are dead-end hosts, clinical manifestations are highly variable ranging from mild influenza-like symptoms to severe multisystemic illness with potentially fatal outcome. At-risk population include farmers and agricultural workers, fishermen, pest exterminators, water sports people, sanitary workers, sewage workers, animal caretakers, abattoir staff. In livestock, the clinical signs of leptospirosis include reduced fertility, stillbirth and abortion. Acute disease in dogs may present with acute kidney injury and liver impairment and respiratory, sometimes also gastrointestinal, signs. Leptospires colonize the kidneys of their host and can therefore be shed via urine into the environment, contaminating water sources.

The diagnosis of leptospirosis is difficult in both the clinic and the laboratory and the global disease burden is thus likely underestimated. In Sweden and Denmark, urban rats were identified as a source for leptospirosis with prevalence rates ranging from 24% to up to 89%, respectively, in recent years. It is believed that leptospirosis does not play a role in Norway but currently, no comprehensive data on leptospirosis in Norway are available to support that and the epidemiological situation including potential maintenance hosts is unknown.  


Our network collaborates on different subprojects:

PhD. student Silje is working on identifying the role of Leptospira in cattle, rodents and shrews in Norway. Moreover, she is studying host-pathogen interactions of Leptospira borgpetersenii serovar Hardjo type hardjobovis in a bovine caruncular epithelial cell line (BCEC-1). Her project will shed light on the current epidemiological situation in Norway and understand the mechanisms that Leptospira use to cause reproductive disease in cattle by harming the placenta.

Our group linked to the HUNT One Health project aims at screening metagenomic data from livestock and pets for the presence of pathogenic Leptospira spp. and, subsequently, will felect this


We have established a qPCR to detect DNA of pathogenic Leptospira species. The qPCR targets a gene encoding outer membrane protein LipL32 and is based on primers and probe described by Stoddard et al. (2013) and Galloway et al. (2015).


 Sabrina Rodriguez Campos
Associate Professor
Project leader
Silje Camilla Furre Hansen
PhD Candidate
PhD student
Mette Myrmel
Co-supervisor PhD student, Collaborator HUNT One Health study, Partner on proposal INSPIRED
Anette Kristine Krogenæs
Co-supervisor PhD student, Collaborator HUNT One Health study
Christiane Pfarrer
Professor, University of Veterinary Medicine Hannover
Collaborator in Silje Hansen's PhD project.
Ann-Katrin Llarena
Associate Professor
Collaborator HUNT One Health study
Anita Haug Haaland
Associate Professor
Collaborator HUNT One Health study
Marie Saito
Postdoctoral Fellow
Partner on proposal INSPIRED



Norwegian Institute of Public Health

Institut Pasteur Paris

Naturformidling van der Kooij

  • Jeroen van der Kooij

Faculty of Chemistry, Biotechnology and Food Science, NMBU


List of publications on Leptospira (co-)authored by the project leader.

Other relevant projects

HUNT One Health

The HUNT- One Health project is a collaboration between NMBU, the Veterinary Institute and NTNU. The project is managed by the Veterinary Institute and is a sub-project of the population health study in Nord-Trøndelag, HUNT4.

The FeedMileage project

The research project aims to increase the efficiency of Norwegian farm animal production by advanced nutritional and genetic methods.


Systems biology will aid sustainability in salmon farming. Scarcity of fish oil has forced development of novel feedstuffs, challenging the salmon's metabolism as well as our understanding of it.

Partners in private and public sector