Norwegian University of Life Sciences
Leptospirosis is considered the most widespread zoonotic disease in the world with a notable (re-)emergence during the past decade. The World Health Organization (WHO) recognizes leptospirosis outbreaks to be driven by climate and environment since warmer and wetter conditions favor the spread of the infection. Leptospira have a broad host range and leptospirosis may present with a broad spectrum of clinical symptoms.
While maintenance hosts like rats generally remain asymptomatic, in humans, who are dead-end hosts, clinical manifestations are highly variable ranging from mild influenza-like symptoms to severe multisystemic illness with potentially fatal outcome. At-risk population include farmers and agricultural workers, fishermen, pest exterminators, water sports people, sanitary workers, sewage workers, animal caretakers, abattoir staff. In livestock, the clinical signs of leptospirosis include reduced fertility, stillbirth and abortion. Acute disease in dogs may present with acute kidney injury and liver impairment and respiratory, sometimes also gastrointestinal, signs. Leptospires colonize the kidneys of their host and can therefore be shed via urine into the environment, contaminating water sources.
The diagnosis of leptospirosis is difficult in both the clinic and the laboratory and the global disease burden is thus likely underestimated. In Sweden and Denmark, urban rats were identified as a source for leptospirosis with prevalence rates ranging from 24% to up to 89%, respectively, in recent years. It is believed that leptospirosis does not play a role in Norway but currently, no comprehensive data on leptospirosis in Norway are available to support that and the epidemiological situation including potential maintenance hosts is unknown.
Our network collaborates on different subprojects:
PhD. student Silje is working on identifying the role of Leptospira in cattle, rodents and shrews in Norway. Moreover, she is studying host-pathogen interactions of Leptospira borgpetersenii serovar Hardjo type hardjobovis in a bovine caruncular epithelial cell line (BCEC-1). Her project will shed light on the current epidemiological situation in Norway and understand the mechanisms that Leptospira use to cause reproductive disease in cattle by harming the placenta.
Our group linked to the HUNT One Health project aims at screening metagenomic data from livestock and pets for the presence of pathogenic Leptospira spp. and, subsequently, will felect this
We have established a qPCR to detect DNA of pathogenic Leptospira species. The qPCR targets a gene encoding outer membrane protein LipL32 and is based on primers and probe described by Stoddard et al. (2013) and Galloway et al. (2015).
External participants
Christiane Pfarrer
Professor, University of Veterinary Medicine Hannover
Collaborator on Silje Hansen's PhD project
Anita Haug Haaland
Collaborator HUNT One Health study
Collaborators
The Norwegian Veterinary Institute
Siv Klevar, researcher and veterinarianThe Norwegian Institue of Public Health
Heidi Elisabeth Heggen Lindstedt, senior advisor, Cand. AgricArnulf Soleng, Senior researcherInstitut Pasteur Paris
Mathieus PicardeauNaturformidling van der Kooij
Jeroen van der Kooij
Faculty of Chemistry, Biotechnology and Food Science, NMBU
Bjørn-Arne Lindstedt
Publications
List of publications on Leptospira (co-)authored by the project leader.
Partners in private and public sector
Other relevant projects
HUNT One Health
The HUNT- One Health project is a collaboration between NMBU, the Veterinary Institute and NTNU. The project is managed by the Veterinary Institute and is a sub-project of the population health study in Nord-Trøndelag, HUNT.