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Pathology of Large Animal Disease Models

The course is cancelled.
NOVA PhD course of 2 ECTS, organised by Páll S. Leifsson, KU-HEALTH.
Dates and location: 25-29 January 2016 in Copenhagen, Denmark.

Janne Karin Brodin
Course Description
The course will be a one-week course based on lectures, histopathological seminars and practicals in gross pathology. The aim of the course is to introduce the student to the pathology of large animal disease models.

Large animals/production animals are increasingly being used in biomedical research. The use of large animal models has several advantages compared to rodent models. Firstly, the size of the animals allows repeated sampling of material and the use of diagnostic and therapeutic techniques that have been developed for use in humans. Secondly, factors like anatomy, nutrient requirement, metabolic rate, general physiological behaviour, pattern of organ development make production animals superior to rodent models.

We will organise a course where there is focus on the pros and cons of large animal models for human and animal diseases and the pathology associated with such use. The purpose is to gather the knowledge and experience of the scientists teaching at the course and present it to the participants in a comprehensive manner in order to bring focus to the area that has long been overshadowed by the pathology of conventional laboratory animals (rodents and rabbits).

The course will consist of lectures, practicals and histopathological seminars. In the lectures, scientists will inform about the use of large animal models in their research. In the practicals there will be focus on the gross pathology of large animal models, and the histopathological seminars will be based on scanned histopathological slides from lesions in large animal models.

Programme Outline
Beforehand, the participants will receive relevant scientific literature in order to prepare them for the course. Each day’s programme will be divided into a theoretical part of 2 to 3 hours and a practical part of approximately 4 hours duration. The topic of the theoretical and the subsequent practical part will be the same in order to ensure that the student will acquire a broad and well-founded knowledge of the subject that is being presented. Apart from a general introduction into animal models, the following subjects will be covered: canine models of idiopathic pulmonary fibrosis and neoplasms; porcine and equine models of osteochondrosis; porcine models of osteomyelitis, endocarditis, nephritis and encephalitis; caprine models of central nervous diseases; models of fracture and wound healing; and large animal models in forensic pathology.

Learning Outcomes
After finishing the course, the participants will have knowledge about the use and pathology of large animal models in biomedical research. They will know the pros and cons of the use of various species under different circumstances, enabling them to base their selection on a scientific basis.
The skills acquired by the participants include macroscopic and histopathological evaluation of pathological disease processes in large animal models.
The major competence acquired by the participants is a deep insight into the pathology and use of large animal models of human disease. They will have the competence to differentiate between various model types and expand the area of large animal models in their future research.

The evaluation of the participants will be based on their presentation of cases at the histopathology and gross pathology seminars.

Pedagogical Approach
The pedagogical approach will be both inductive (lectures) and deductive (seminars). Inter-participant discussions will be encouraged with presentation of cases by participants under the supervision of a senior scientist.

Estimated Workload

  • 14 hours seminar (histopathology)
  • 3 hours seminar (gross pathology)
  • 14½ hours lecture
  • 27 hours independent work
  • 1½ hours other (introduction and evaluation)

Prerequisite Knowledge
The participants should have master’s degree or an equivalent education in veterinary medicine.

Admission for NOVA courses is handled by the course organiser/ the NOVA member institution organising the course. Please see the links in the margin for more information.

Published 6. August 2015 - 15:12 - Updated 23. May 2017 - 19:19