Survey about Adverse Outcome Pathways

NEA’s RAD/CHEM Topical groups are working together to advance the use of AOPs in radiation research and regulations. But to do that, we need input from people like you.

We kindly invite you to submit any questions you may have on the Adverse Outcome Pathway by following the Survey Link before September 17th. The survey should only take 5 minutes to complete!

If you want to learn more about AOPs and the Horizon project first, we invite you to watch this webinar, delivered to the Radiation Research Society.


About International Horizon-style Exercise to Evolve the Use of the Adverse Outcome Pathway (AOP) Framework in Radiation Research and Regulation

In 2012, the OECD launched a new programme on the development of Adverse Outcome Pathways (AOPs), a concept which describes a sequence of causally linked events that occur in response to a biological perturbation and lead to an adverse health outcome relevant to risk assessment, regulatory decision making and/or environmental management.

In this context, the NEA High-Level Group on Low Dose Research (HLG-LDR) and its RAD/CHEM AOP joint topical group are conducting a public survey to gather insights on the challenges related to low-dose radiation research, risk assessment and regulatory decision making.

This survey is part of a horizon-style exercise which aims to identify emerging trends, opportunities, limitations and solutions that impact the future directions of AOP development and its use in the fields of radiation research, policy and regulation. The exercise involves two phases: 1) research question solicitation and 2) an international survey of radiation professionals.

The survey targets a broad and international audience representing current and future stakeholder groups (including the public, private and academic sectors, as well as non-governmental organisations) that are involved in or may be impacted by the AOP concept and its potential applications in radiation risk assessment and regulation. 

The objectives of the horizon-style exercise are:

  • to expand awareness, involvement and application of AOPs in radiation hazard and risk assessment;
  • to identify key themes, knowledge domains and gaps for AOP-directed research;
  • to identify challenges, limitations and solutions for advancement; and,
  • to identify how to pragmatically support the development and use of AOPs in research and regulations.

How will the survey results be used?

“What areas can the AOP approach support? What are the challenges, limitations and solutions? How can the HLG-LDR RAD/CHEM joint topical group facilitate the development and use of AOPs?” These are few examples of questions the survey aims to answer. With these questions, the exercise will:
  • inform the NEAs HLG-LDR’s work to engage, promote and develop AOPs in the field of radiation;
  • inform the development of AOP-focused workshops involving experts from the research and regulatory community;
  • support the international dissemination of collected responses in international journals, among professional societies and during meetings.

The survey is open to individuals, institutions and professional societies until 17 September 2021. The survey is managed by the Canadian Nuclear Safety Commission (CNSC), with the financial support of the Canadian Organization on Health Effects from Radiation Exposure (COHERE).

Published 24. August 2021 - 9:14 - Updated 24. August 2021 - 9:14