Review on gonadotrope plasticity

This review summarizes current knowledge of the effects of sex steroids (androgens and estrogens) on gonadotrope cell plasticity in the teleost pituitary. Indeed, sex steroids, produced mainly by the gonadal steroidogenic cells, have been shown to exert complex effects on the teleost pituitary and especially gonadotropes which regulate gametogenesis and steroidogenesis, with differential effects depending on the species investigated, physiological status or sex of the animal, and dose or method of administration. In addition, pituitary plasticity is achieved at both cellular and population levels. At the cellular level, hormone synthesis and release can be regulated via changes in cell composition to modulate both sensitivity and response to different signals. At the cell population level, the number of cells producing a given hormone can change due to proliferation, differentiation of progenitor cells, or transdifferentiation of specific cell types. Therefore, this review discusses the different types of plasticity observed in gonadotropes in teleost fishes, discriminating direct from indirect effects.

Full publication: Romain Fontaine, Muhammad Rahmad Royan, Kristine von Krogh, Finn-Arne Weltzien & Dianne M. Baker (2020) Direct and indirect effects of sex steroids on gonadotrope cell plasticity in the teleost fish pituitary. Frontiers in Endocrinology 11, 605068. doi 10.3389/fendo.2020.605068

Published 14. December 2020 - 13:35 - Updated 14. December 2020 - 13:35