Bacterial biofilms

Associated projects:

 

DISRUPT: Fighting antimicrobial-resistant infections by the discovery of biofilm-disrupting agents

  
Bacterial infections that are related to biofilms (bacterial communities that form a dense coating on diverse surfaces) are difficult to treat with current antibiotic strategies. All the more so when drug resistant bacteria are involved. New strategies and compounds to fight such resilient infections are sorely needed. But the full repertoire of genes and processes that are essential for biofilm formation in different microbes is still unknown. We develop new approaches and genetic tools to identify novel anti-biofilm targets and agents in four major antimicrobial resistant pathogens: Staphylococci, Pneumococci, E. coli and Pseudomonas.
 
The consortium project involves labs in Norway (Norwegian Unversity of Life Sciences), Switzerland (University of Lausanne) and Germany (EMBL, Heidelberg). .
 
For more information, visit the official DISRUPT website
 

BOB: The role of bacteriocins in shaping of oral biofilms

BOB is MSCA postdoctoral project awarded to Sara Arbulu
 

Bacteriocins are antimicrobial peptides produced by bacteria primarily known as killer peptides and known to be important for competition between bacterial strains and species. They have been widely studied as a potential alternative or complement to antibiotics and as food preservatives. However, little is known about their ecological role in shaping biofilm communities and their influence on the microbe-microbe dialogue.

This project will interrogate how bacteriocins, and particularly bacteriocin immunity proteins (which protect the bacteriocin-producing bacteria from its own bacteriocins), influence bacterial interactions during biofilm formation using oral streptococci biofilms as a model. Bacteriocin genes and specifically immunity genes may represent potential therapeutic (anti-biofilm) targets debilitating bacteria or enhancing the activity of antimicrobials against disease-causing microorganisms.

Published 26. November 2019 - 13:03 - Updated 8. April 2022 - 16:12