DISRUPT: Fighting antimicrobial-resistant infections by the discovery of biofilm-disrupting agents
BOB: The role of bacteriocins in shaping of oral biofilms
Bacteriocins are antimicrobial peptides produced by bacteria primarily known as killer peptides and known to be important for competition between bacterial strains and species. They have been widely studied as a potential alternative or complement to antibiotics and as food preservatives. However, little is known about their ecological role in shaping biofilm communities and their influence on the microbe-microbe dialogue.
This project will interrogate how bacteriocins, and particularly bacteriocin immunity proteins (which protect the bacteriocin-producing bacteria from its own bacteriocins), influence bacterial interactions during biofilm formation using oral streptococci biofilms as a model. Bacteriocin genes and specifically immunity genes may represent potential therapeutic (anti-biofilm) targets debilitating bacteria or enhancing the activity of antimicrobials against disease-causing microorganisms.